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Verfasst von:Sobeh, Mansour [VerfasserIn]   i
 Youssef, Fadia S. [VerfasserIn]   i
 Esmat, Ahmed [VerfasserIn]   i
 Petruk, Ganna [VerfasserIn]   i
 El-Khatib, Ahmed H. [VerfasserIn]   i
 Monti, Daria Maria [VerfasserIn]   i
 Ashour, Mohamed L. [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
Titel:High resolution UPLC-MS/MS profiling of polyphenolics in the methanol extract of Syzygium samarangense leaves and its hepatoprotective activity in rats with CCl4-induced hepatic damage
Verf.angabe:Mansour Sobeh, Fadia S. Youssef, Ahmed Esmat, Ganna Petruk, Ahmed H. El-Khatib, Daria Maria Monti, Mohamed L. Ashour, Michael Wink
E-Jahr:2018
Jahr:31 January 2018
Umfang:9 S.
Fussnoten:Gesehen am 17.12.2019 ; Im Titel ist die Zahl 4 tiefgestellt dargestellt ; Syzygium samarangense ist kursiv dargestellt
Titel Quelle:Enthalten in: Food and chemical toxicology
Ort Quelle:New York, NY [u.a.] : Elsevier, 1982
Jahr Quelle:2018
Band/Heft Quelle:113(2018), Seite 145-153
ISSN Quelle:1873-6351
Abstract:Oxidative stress plays a crucial role in the development of several liver diseases. Many natural polyphenols can attenuate oxidative stress and liver injury. In this study, a phytochemical profiling of a methanol extract from leaves of Syzygium samarangense revealed 92 compounds belonging to flavonoids, phenolic acids, condensed tannins, and ellagitannins. The S. samarangense extract exhibited a noticeable antioxidant activity with an EC50 of 5.80μg/mL measured by DPPH scavenging capacity assay, 2632 Trolox equivalents, 10mM Fe2+ equivalents/mg of samples by TEAC and FRAP assays, respectively. The total phenolic content was 419mg gallic acid equivalent GAE/g extract. In a cell-based model (HaCaT cells), the extract completely inhibited ROS production induced by UVA, and prevented GSH-depletion and p38 phosphorylation. In addition, the extract exhibited a substantial antioxidant and hepatoprotective activities in CCl4-treated rats, with an increase in GSH (reduced glutathione) and SOD (superoxide dismutase) activities by 84.75 and 26.27%, respectively, and a decrease of 19.08, 63.05, 52.21, 37.00, 13.26, and 15.15% in MDA, ALT, AST, TB (total bilirubin), TC (total cholesterol), and TG (total glycerides), respectively. These results were confirmed by histopathological analyses. We believe that Syzygium samarangense is a good candidate for further evaluation as an antioxidant and liver protecting drug.
DOI:doi:10.1016/j.fct.2018.01.031
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.fct.2018.01.031
 Verlag: http://www.sciencedirect.com/science/article/pii/S0278691518300310
 DOI: https://doi.org/10.1016/j.fct.2018.01.031
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Antioxidant
 Carbon tetrachloride toxicity
 HaCaT cells
 Hepatoprotective activity
 HR-UPLC-MS/MS
K10plus-PPN:1685778119
Verknüpfungen:→ Zeitschrift

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