Quantizing single-molecule surface-enhanced Raman scattering with DNA origami metamolecules

• Verfasst von: Fang, Weina [VerfasserIn]
• Verfasst von: Duan, Xiaoyang [VerfasserIn]
• Verfasst von: Liu, Na [VerfasserIn]
• Titel: Quantizing single-molecule surface-enhanced Raman scattering with DNA origami metamolecules
• Verf.angabe: Weina Fang, Sisi Jia, Jie Chao, Liqian Wang, Xiaoyang Duan, Huajie Liu, Qian Li, Xiaolei Zuo, Lihua Wang, Lianhui Wang, Na Liu, Chunhai Fan
• E-Jahr: 2019
• Jahr: [27 September 2019]
• Umfang: 8 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 23.12.2019
• Titel Quelle: Enthalten in: Science advances
• Ort Quelle: Washington, DC [u.a.] : Assoc., 2015
• Jahr Quelle: 2019
• Band/Heft Quelle: 5(2019,9) Artikel-Nummer eaau4506, Seite 1-8, 8 Seiten
• ISSN Quelle: 2375-2548
• DOI: doi:10.1126/sciadv.aau4506
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1686327226

Abstract

Tailored metal nanoclusters have been actively developed to manipulate light at the subwavelength scale for nanophotonic applications. Nevertheless, precise arrangement of molecules in a hot spot with fixed numbers and positions remains challenging. Here, we show that DNA origami metamolecules with Fano resonances (DMFR) can precisely localize single dye molecules and produce quantified surface-enhanced Raman scattering (SERS) responses. To enable tailored plasmonic permutations, we develop a general and programmable method for anchoring a set of large gold nanoparticles (L-AuNPs) on prescribed n-tuple docking sites of super-origami DNA frameworks. A tetrameric nanocluster with four spatially organized 80-nm L-AuNPs exhibits peak-and-dip Fano characteristics. The drastic enhancement at the wavelength of the Fano minimum allows the collection of prominent SERS spectrum for even a single dye molecule. We expect that DMFR provides physical insights into single-molecule SERS and opens new opportunities for developing plasmonic nanodevices for ultrasensitive sensing, nanocircuits, and nanophotonic lasers. - Plasmonic nanostructures supporting strong spatially confined field enhancement are developed to probe single-molecule SERS. - Plasmonic nanostructures supporting strong spatially confined field enhancement are developed to probe single-molecule SERS.