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Verfasst von:Duangjan, Chatrawee [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
Titel:Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways
Verf.angabe:Chatrawee Duangjan, Panthakarn Rangsinth, Xiaojie Gu, Shaoxiong Zhang, Michael Wink, Tewin Tencomnao
E-Jahr:2019
Jahr:31 July 2019
Umfang:8 S.
Fussnoten:Available online 31 July 2019 ; Gesehen am 08.01.2020
Titel Quelle:Enthalten in: Phytomedicine
Ort Quelle:München [u.a.] : Elsevier, 1994
Jahr Quelle:2019
Band/Heft Quelle:64(2019) Artikel-Nummer 153061, 8 Seiten
ISSN Quelle:1618-095X
Abstract:Background - Glochidion zeylanicum (GZ), a common plant in Thailand and Eastern Asia, is rich in antioxidants. However, the possible anti-aging and oxidative stress resistance properties of GZ leaf extracts (hexane and methanol extracts) have not been reported. - Purpose - We aimed to provide the first science-based evidence of the beneficial effects of GZ on anti-aging and oxidative stress resistance in the Caenorhabditis elegans model. - Methods - The phytochemical composition of the hexane and methanol extracts were analyzed using GLC-MS and LC-MS. Fingerprinting analysis of the extract was performed by RP-HPLC. We determined total phenolics, flavonoids, and antioxidant properties via DPPH and ABTS assays. Oxidative stress resistance, anti-aging and lifespan were studied in C. elegans treated with leaf extracts. - Results - GZ leaf extracts protected the worms against oxidative stress and attenuated ROS accumulation. The expression of stress-response genes, such as SOD-3, and GST-4 were up-regulated, whereas HSP-16.2 was down-regulated after GZ treatment. The oxidative stress resistance properties of GZ possibly involved the DAF-16/FoxO and SKN-1/Nrf-2 transcription factors. GZ leaf extracts improved pharyngeal pumping function and autofluorescent pigment attenuation suggesting anti-aging properties. GZ leaf extracts modulated the lifespan extension in C. elegans. - Conclusion - This study reports novel anti-aging and antioxidant activities of GZ leaf extracts, suggesting a novel bioactivity for a medicinally important plant and supplementary drug against oxidative stress.
DOI:doi:10.1016/j.phymed.2019.153061
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.phymed.2019.153061
 Verlag: http://www.sciencedirect.com/science/article/pii/S0944711319302272
 DOI: https://doi.org/10.1016/j.phymed.2019.153061
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aging
 Antioxidants
 DAF-16/FoxO
 SKN-1/Nrf2
K10plus-PPN:1686665172
Verknüpfungen:→ Zeitschrift

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