Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Duangjan, Chatrawee [VerfasserIn]  |
| Wink, Michael [VerfasserIn]  |
Titel: | Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways |
Verf.angabe: | Chatrawee Duangjan, Panthakarn Rangsinth, Xiaojie Gu, Shaoxiong Zhang, Michael Wink, Tewin Tencomnao |
E-Jahr: | 2019 |
Jahr: | 31 July 2019 |
Umfang: | 8 S. |
Fussnoten: | Available online 31 July 2019 ; Gesehen am 08.01.2020 |
Titel Quelle: | Enthalten in: Phytomedicine |
Ort Quelle: | München [u.a.] : Elsevier, 1994 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 64(2019) Artikel-Nummer 153061, 8 Seiten |
ISSN Quelle: | 1618-095X |
Abstract: | Background - Glochidion zeylanicum (GZ), a common plant in Thailand and Eastern Asia, is rich in antioxidants. However, the possible anti-aging and oxidative stress resistance properties of GZ leaf extracts (hexane and methanol extracts) have not been reported. - Purpose - We aimed to provide the first science-based evidence of the beneficial effects of GZ on anti-aging and oxidative stress resistance in the Caenorhabditis elegans model. - Methods - The phytochemical composition of the hexane and methanol extracts were analyzed using GLC-MS and LC-MS. Fingerprinting analysis of the extract was performed by RP-HPLC. We determined total phenolics, flavonoids, and antioxidant properties via DPPH and ABTS assays. Oxidative stress resistance, anti-aging and lifespan were studied in C. elegans treated with leaf extracts. - Results - GZ leaf extracts protected the worms against oxidative stress and attenuated ROS accumulation. The expression of stress-response genes, such as SOD-3, and GST-4 were up-regulated, whereas HSP-16.2 was down-regulated after GZ treatment. The oxidative stress resistance properties of GZ possibly involved the DAF-16/FoxO and SKN-1/Nrf-2 transcription factors. GZ leaf extracts improved pharyngeal pumping function and autofluorescent pigment attenuation suggesting anti-aging properties. GZ leaf extracts modulated the lifespan extension in C. elegans. - Conclusion - This study reports novel anti-aging and antioxidant activities of GZ leaf extracts, suggesting a novel bioactivity for a medicinally important plant and supplementary drug against oxidative stress. |
DOI: | doi:10.1016/j.phymed.2019.153061 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.phymed.2019.153061 |
| Verlag: http://www.sciencedirect.com/science/article/pii/S0944711319302272 |
| DOI: https://doi.org/10.1016/j.phymed.2019.153061 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Aging |
| Antioxidants |
| DAF-16/FoxO |
| SKN-1/Nrf2 |
K10plus-PPN: | 1686665172 |
Verknüpfungen: | → Zeitschrift |
Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways / Duangjan, Chatrawee [VerfasserIn]; 31 July 2019 (Online-Ressource)
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