Stimulation of innate immunity by host and viral RNAs

• Verfasst von: Streicher, Felix [VerfasserIn]
• Verfasst von: Jouvenet, Nolwenn [VerfasserIn]
• Titel: Stimulation of innate immunity by host and viral RNAs
• Verf.angabe: Felix Streicher and Nolwenn Jouvenet
• E-Jahr: 2019
• Jahr: 14 November 2019
• Umfang: 15 S.
• Fussnoten: Gesehen am 10.01.2020
• Titel Quelle: Enthalten in: Trends in immunology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 2001
• Jahr Quelle: 2019
• Band/Heft Quelle: 40(2019), 12, Seite 1134-1148
• ISSN Quelle: 1471-4981
• DOI: doi:10.1016/j.it.2019.10.009
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: antiviral response
• Sach-SW: endogenous immunostimulatory RNAs
• Sach-SW: innate immune response
• Sach-SW: interferon
• Sach-SW: RIG-I-like receptors
• Sach-SW: RNA processing
• Sach-SW: viral immunostimulatory RNAs
• Sach-SW: viruses
• K10plus-PPN: 1686993269

Abstract

The interferon (IFN) response, a major vertebrate defense mechanism against viral infections, is initiated by RIG-I-like receptor (RLR)-mediated recognition of viral replicative intermediates in the cytosol. RLR purification methods coupled to RNA sequencing have recently led to the characterization of viral nucleic acid features recognized by RLRs in infected cells. This work revealed that some cellular RNAs can bind to RLRs and stimulate the IFN response. We provide an overview of self and non-self RNAs that activate innate immunity, and discuss the cellular dysregulation that allows recognition of cellular RNAs by RLRs, including RNA mislocalization and downregulation of RNA-shielding proteins. These discussions are relevant because manipulating RLR activation presents opportunities for treating viral infections and autoimmune disorders.