Multimodality cardiac computed tomography angiography and magnetic resonance with clinical-grade scanners provide robust assessment of cardiac morphology and function in rabbits

• Verfasst von: Gitsioudis, Gitsios [VerfasserIn]
• Verfasst von: Nunninger, Maximilian Martin [VerfasserIn]
• Verfasst von: Missiou, Anna [VerfasserIn]
• Verfasst von: Wolf, Peter Georg [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Korosoglou, Grigorios [VerfasserIn]
• Titel: Multimodality cardiac computed tomography angiography and magnetic resonance with clinical-grade scanners provide robust assessment of cardiac morphology and function in rabbits
• Verf.angabe: Gitsios Gitsioudis, Maximilian Nunninger, Anna Missiou, Peter Wolf, Hugo A. Katus, Grigorios Korosoglou
• E-Jahr: 2019
• Jahr: 26 August 2019
• Umfang: 10 S.
• Fussnoten: Gesehen am 14.01.2020
• Titel Quelle: Enthalten in: Journal of thoracic disease
• Ort Quelle: Hong Kong : Pioneer Bioscience Publ., 2009
• Jahr Quelle: 2019
• Band/Heft Quelle: 11(2019), 11, Seite 4762-4771
• ISSN Quelle: 2077-6624
• DOI: doi:10.21037/jtd.2019.10.46
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 168730467X

Abstract

Background: Non-invasive computer tomography (CT)- and magnetic resonance (MR)-based cardiac imaging still remains challenging in rodents. To investigate the robustness of non-invasive multimodality cardiac imaging in rabbits using clinical-grade CT and MR scanners. - Methods: A total of 16 rabbits (2.7-4.0 kg) serially underwent cardiac-gated imaging using a clinical-grade 256-row CT and a 1.5 Tesla MR-scanner at baseline and at 4-month follow-up (16±1 weeks). Image analysis included image quality (5-grade scale), left ventricular (LV) volumes, LV stroke volume, LV diameters, LV wall thickness and ejection fraction (LVEF). - Results: Cardiac MR (CMR) and CT angiography (CTA) provide images with an overall good image quality (excellent or good quality: CMR 82% vs. CTA 78%, P=0.68). Linear regression analysis demonstrated a good correlation of all diameters (diam.) and volumes (vol.) as assessed by CTA and CMR (diam.: r=0.9, 95% CI: 0.8-0.9; vol.: r=0.8, 95% CI: 0.6-0.9; P Conclusions: Multimodality non-invasive assessment of cardiac function and aortic hemodynamics is feasible and robust in rabbits using clinical-grade and MR and CT scanners. These imaging modalities could improve serial cardiac assessment for disease monitoring in preclinical settings.