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Status: Bibliographieeintrag

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Verfasst von:Hien, Andreas [VerfasserIn]   i
 Pretze, Marc [VerfasserIn]   i
 Braun, Frank [VerfasserIn]   i
 Schäfer, Edgar [VerfasserIn]   i
 Kümmel, Tim [VerfasserIn]   i
 Roscher, Mareike [VerfasserIn]   i
 Schock-Kusch, Daniel [VerfasserIn]   i
 Waldeck, Jens [VerfasserIn]   i
 Müller, Bernhard [VerfasserIn]   i
 Wängler, Carmen [VerfasserIn]   i
 Rädle, Matthias [VerfasserIn]   i
 Wängler, Björn [VerfasserIn]   i
Titel:Noncontact recognition of fluorescently labeled objects in deep tissue via a novel optical light beam arrangement
Verf.angabe:Andreas Hien, Marc Pretze, Frank Braun, Edgar Schäfer, Tim Kümmel, Mareike Roscher, Daniel Schock-Kusch, Jens Waldeck, Bernhard Müller, Carmen Wängler, Matthias Rädle, Björn Wängler
E-Jahr:2018
Jahr:December 19, 2018
Umfang:18 S.
Fussnoten:Published: December 19, 2018 ; Gesehen am 14.01.2020
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2018
Band/Heft Quelle:13(2018,12) Artikel-Nummer e0208236, 18 Seiten
ISSN Quelle:1932-6203
Abstract:To date, few optical imaging systems are available in clinical practice to perform noninvasive measurements transcutaneously. Instead, functional imaging is performed using ionizing radiation or intense magnetic fields in most cases. The applicability of fluorescence imaging (e.g., for the detection of fluorescently labeled objects, such as tumors) is limited due to the restricted tissue penetration of light and the required long exposure time. Thus, the development of highly sensitive and easily manageable instruments is necessary to broaden the utility of optical imaging. To advance these developments, an improved fluorescence imaging system was designed in this study that operates on the principle of noncontact laser-induced fluorescence and enables the detection of fluorescence from deeper tissue layers as well as real-time imaging. The high performance of the developed optical laser scanner results from the combination of specific point illumination, an intensified charge-coupled device (ICCD) detector with a novel light trap, and a filtering strategy. The suitability of the laser scanner was demonstrated in two representative applications and an in vivo evaluation. In addition, a comparison with a planar imaging system was performed. The results show that the exposure time with the developed laser scanner can be reduced to a few milliseconds during measurements with a penetration depth of up to 32 mm. Due to these short exposure times, real-time fluorescence imaging can be easily achieved. The ability to measure fluorescence from deep tissue layers enables clinically relevant applications, such as the detection of fluorescently labeled malignant tumors.
DOI:doi:10.1371/journal.pone.0208236
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1371/journal.pone.0208236
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208236
 DOI: https://doi.org/10.1371/journal.pone.0208236
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Artificial light
 Bright field imaging
 Fluorescence
 Fluorescence imaging
 In vivo imaging
 Lasers
 Light
 Magnetic resonance imaging
K10plus-PPN:1687304971
Verknüpfungen:→ Zeitschrift

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