| |  Online-Ressource |
|---|
| Verfasst von: | Hillen, Uwe [VerfasserIn]  |
|---|
| | Leiter, Ulrike [VerfasserIn] |
|---|
| | Haase, Sylvie [VerfasserIn] |
|---|
| | Kaufmann, Roland [VerfasserIn] |
|---|
| | Becker, Jürgen [VerfasserIn] |
|---|
| | Gutzmer, Ralf [VerfasserIn] |
|---|
| | Terheyden, Patrick [VerfasserIn] |
|---|
| | Krause-Bergmann, Albrecht [VerfasserIn] |
|---|
| | Schulze, Hans-Joachim [VerfasserIn] |
|---|
| | Hassel, Jessica C. [VerfasserIn] |
|---|
| | Lahner, Nina [VerfasserIn] |
|---|
| | Wollina, Uwe [VerfasserIn] |
|---|
| | Ziller, Fabian [VerfasserIn] |
|---|
| | Utikal, Jochen [VerfasserIn] |
|---|
| | Hafner, Christine [VerfasserIn] |
|---|
| | Ulrich, Jens [VerfasserIn] |
|---|
| | Machens, Hans-Günther [VerfasserIn] |
|---|
| | Weishaupt, Carsten [VerfasserIn] |
|---|
| | Hauschild, Axel [VerfasserIn] |
|---|
| | Mohr, Peter [VerfasserIn] |
|---|
| | Pföhler, Claudia [VerfasserIn] |
|---|
| | Maurer, Jan [VerfasserIn] |
|---|
| | Wolff, Patrick [VerfasserIn] |
|---|
| | Windemuth-Kieselbach, Christine [VerfasserIn] |
|---|
| | Schadendorf, Dirk [VerfasserIn] |
|---|
| | Livingstone, Elisabeth [VerfasserIn] |
|---|
| Titel: | Advanced cutaneous squamous cell carcinoma |
|---|
| Titelzusatz: | a retrospective analysis of patient profiles and treatment patterns : results of a non-interventional study of the DeCOG |
|---|
| Verf.angabe: | Jessica Hassel, Nina Lahner, Uwe Wollina, Fabian Ziller, Jochen Utikal, Christine Hafner, Jens Ulrich, Hans-Günther Machens, Carsten Weishaupt, Axel Hauschild, Peter Mohr, Claudia Pföhler, Jan Maurer, Patrick Wolff, Christine Windemuth-Kieselbach, Dirk Schadendorf, Elisabeth Livingstone |
|---|
| E-Jahr: | 2018 |
|---|
| Jahr: | 14 April 2018 |
|---|
| Umfang: | 10 S. |
|---|
| Fussnoten: | Available online 14 April 2018 ; Gesehen am 15.01.2020 |
|---|
| Titel Quelle: | Enthalten in: European journal of cancer |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1992 |
|---|
| Jahr Quelle: | 2018 |
|---|
| Band/Heft Quelle: | 96(2018), Seite 34-43 |
|---|
| ISSN Quelle: | 1879-0852 |
|---|
| Abstract: | Background - Advanced cutaneous squamous cell carcinoma (aSCC) is an area of unmet medical need and no treatment standards are established. Recently, an anti-PD-1 inhibitor received FDA breakthrough therapy designation. The aim of the study was to describe the clinical course, therapeutic management and prognosis of aSCC under real-life conditions. - Patients and methods - In a retrospective study performed in 24 German and Austrian hospitals and doctor's offices, patient and tumour characteristics of patients diagnosed with aSCC between January 1, 2010 and December 31, 2011 and their disease course was documented. Advanced SCC comprised either locally advanced SCCs (laSCC) or metastatic SCCs (mSCC) with any kind of metastatic spread. - Results - Data of 190 patients with aSCC were analysed. Median age at time of diagnosis of aSCC was 78 years. LaSCC was diagnosed in 76 patients (40%), 114 patients (60%) had mSCC. Once diagnosed with laSCC, most patients (59%) did not receive any therapy, whereas in 92% of mSCC patients at least one type of therapy was performed. Only 32 patients (29 mSCC, 3 laSCC) received systemic antitumour therapies, mostly EGFR inhibitor-based regimens. Mean duration of response was short (17-months laSCC patients, 3-months mSCC patients). Only 2 patients achieved a complete response, 27% had a partial response, 43% disease stabilisation. At diagnosis of aSCC, ECOG status was 0-1 in most patients. Non-malignant comorbidities influenced the decision on SCC-specific therapy in 39 patients (21%). - Conclusions - Our data show the high medical need for efficient and tolerable antitumour therapies and demonstrate that despite older age and comorbidities, most patients can be expected to be fit for treatment. This study provides a historical context for emerging aSCC treatments. |
|---|
| DOI: | doi:10.1016/j.ejca.2018.01.075 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejca.2018.01.075 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0959804918300893 |
|---|
| | DOI: https://doi.org/10.1016/j.ejca.2018.01.075 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Epidemiology |
|---|
| | Non-melanoma skin cancer |
|---|
| | Squamous cell carcinoma |
|---|
| | Survival |
|---|
| | Treatment |
|---|
| K10plus-PPN: | 1687411891 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Advanced cutaneous squamous cell carcinoma / Hillen, Uwe [VerfasserIn]; 14 April 2018 (Online-Ressource)
