| |  Online-Ressource |
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| Verfasst von: | Moratin, Julius [VerfasserIn]  |
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| | Safaltin, Ayse [VerfasserIn] |
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| | Herpel, Esther [VerfasserIn] |
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| | Hoffmann, Jürgen [VerfasserIn] |
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| | Freier, Kolja [VerfasserIn] |
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| | Heß, Jochen [VerfasserIn] |
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| | Horn, Dominik [VerfasserIn] |
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| Titel: | Upregulation of PD-L1 and PD-L2 in neck node metastases of head and neck squamous cell carcinoma |
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| Mitwirkende: | Semmelmayer, Karl |
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| Verf.angabe: | Julius Moratin MD, DMD, Karl Metzger DMD, Ayse Safaltin DMD, Esther Herpel MD, Jürgen Hoffmann MD, DMD, Kolja Freier MD, DMD, Jochen Hess PhD, Dominik Horn MD, DMD |
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| E-Jahr: | 2019 |
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| Jahr: | 01 March 2019 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 17.01.2020 |
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| Titel Quelle: | Enthalten in: Head & neck |
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| Ort Quelle: | New York, NY : Wiley, 1989 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 41(2019), 8, Seite 2484-2491 |
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| ISSN Quelle: | 0148-6403 |
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| | 1043-3074 |
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| Abstract: | Background This study aimed on evaluating the expression levels of the immune checkpoint proteins, PD-L1 and PD-L2, in tissue specimens of 175 oral squamous cell carcinomas (OSCC) and 33 corresponding lymph node metastases (LNM). Methods Tissue microarrays of primary OSCC and matched LNM were investigated via immunohistochemistry regarding PD-L1/PD-L2 expression. Results were compared for primary tumors and corresponding metastases and correlated with clinicopathological data. Results PD-L1 expression in cancer cells correlated significantly with tumor size, and the presence of regional metastases (P < 0.01). PD-L1 expression was significantly higher in metastases as compared to primary OSCC (P < 0.05). Overall survival was significantly worse in patients with higher levels of PD-L1 and PD-L2 score (P < 0.05). Conclusions This is the first publication to compare PD-L1 and PD-L2 expression in primary OSCC and matched LNM. The results indicate that anti-PD-1 therapy may be of therapeutic use even in early stage OSCC to prevent further progression. |
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| DOI: | doi:10.1002/hed.25713 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/hed.25713 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25713 |
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| | DOI: https://doi.org/10.1002/hed.25713 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | HNSCC |
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| | immune checkpoint |
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| | lymph node metastases |
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| | PD-L1 |
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| | PD-L2 |
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| K10plus-PPN: | 1687668698 |
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| Verknüpfungen: | → Zeitschrift |
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Upregulation of PD-L1 and PD-L2 in neck node metastases of head and neck squamous cell carcinoma / Moratin, Julius [VerfasserIn]; 01 March 2019 (Online-Ressource)
