| |  Online-Ressource |
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| Verfasst von: | Venkatesh, Humsa [VerfasserIn]  |
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| | Morishita, Wade [VerfasserIn] |
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| | Geraghty, Anna C. [VerfasserIn] |
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| | Silverbush, Dana [VerfasserIn] |
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| | Gillespie, Shawn M. [VerfasserIn] |
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| | Arzt, Marlene [VerfasserIn] |
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| | Tam, Lydia T. [VerfasserIn] |
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| | Espenel, Cedric [VerfasserIn] |
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| | Ponnuswami, Anitha [VerfasserIn] |
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| | Ni, Lijun [VerfasserIn] |
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| | Woo, Pamelyn J. [VerfasserIn] |
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| | Taylor, Kathryn R. [VerfasserIn] |
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| | Agarwal, Amit [VerfasserIn] |
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| | Regev, Aviv [VerfasserIn] |
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| | Brang, David [VerfasserIn] |
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| | Vogel, Hannes [VerfasserIn] |
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| | Hervey-Jumper, Shawn [VerfasserIn] |
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| | Bergles, Dwight E. [VerfasserIn] |
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| | Suvà, Mario L. [VerfasserIn] |
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| | Malenka, Robert C. [VerfasserIn] |
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| | Monje, Michelle [VerfasserIn] |
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| Titel: | Electrical and synaptic integration of glioma into neural circuits |
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| Verf.angabe: | Humsa S. Venkatesh, Wade Morishita, Anna C. Geraghty, Dana Silverbush, Shawn M. Gillespie, Marlene Arzt, Lydia T. Tam, Cedric Espenel, Anitha Ponnuswami, Lijun Ni, Pamelyn J. Woo, Kathryn R. Taylor, Amit Agarwal, Aviv Regev, David Brang, Hannes Vogel, Shawn Hervey-Jumper, Dwight E. Bergles, Mario L. Suvà, Robert C. Malenka, Michelle Monje |
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| E-Jahr: | 2019 |
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| Jahr: | 18 September 2019 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 17.01.2020 |
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| Titel Quelle: | Enthalten in: Nature <London> |
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| Ort Quelle: | London [u.a.] : Nature Publ. Group, 1869 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 573(2019), 7775, Seite 539-545 |
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| ISSN Quelle: | 1476-4687 |
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| Abstract: | High-grade gliomas are lethal brain cancers whose progression is robustly regulated by neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but this alone is insufficient to explain the effect that neuronal activity exerts on glioma progression. Here we show that neuron and glioma interactions include electrochemical communication through bona fide AMPA receptor-dependent neuron-glioma synapses. Neuronal activity also evokes non-synaptic activity-dependent potassium currents that are amplified by gap junction-mediated tumour interconnections, forming an electrically coupled network. Depolarization of glioma membranes assessed by in vivo optogenetics promotes proliferation, whereas pharmacologically or genetically blocking electrochemical signalling inhibits the growth of glioma xenografts and extends mouse survival. Emphasizing the positive feedback mechanisms by which gliomas increase neuronal excitability and thus activity-regulated glioma growth, human intraoperative electrocorticography demonstrates increased cortical excitability in the glioma-infiltrated brain. Together, these findings indicate that synaptic and electrical integration into neural circuits promotes glioma progression. |
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| DOI: | doi:10.1038/s41586-019-1563-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1038/s41586-019-1563-y |
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| | DOI: https://doi.org/10.1038/s41586-019-1563-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1687673497 |
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| Verknüpfungen: | → Zeitung |
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Electrical and synaptic integration of glioma into neural circuits / Venkatesh, Humsa [VerfasserIn]; 18 September 2019 (Online-Ressource)
