Transdiagnostic modulation of brain networks by electroconvulsive therapy in schizophrenia and major depression

• Verfasst von: Sambataro, Fabio [VerfasserIn]
• Verfasst von: Thomann, Philipp [VerfasserIn]
• Verfasst von: Nolte, Henrike Maria [VerfasserIn]
• Verfasst von: Hasenkamp, Julia H. [VerfasserIn]
• Verfasst von: Hirjak, Dusan [VerfasserIn]
• Verfasst von: Kubera, Katharina Maria [VerfasserIn]
• Verfasst von: Hofer, Stefan [VerfasserIn]
• Verfasst von: Seidl, Ulrich [VerfasserIn]
• Verfasst von: Depping, Malte S. [VerfasserIn]
• Verfasst von: Stieltjes, Bram [VerfasserIn]
• Verfasst von: Maier-Hein, Klaus H. [VerfasserIn]
• Verfasst von: Wolf, Robert Christian [VerfasserIn]
• Titel: Transdiagnostic modulation of brain networks by electroconvulsive therapy in schizophrenia and major depression
• Verf.angabe: Fabio Sambataro, Philipp Arthur Thomann, Henrike Maria Nolte, JH Hasenkamp, Dusan Hirjak, Katharina M. Kubera, Stefan Hofer, Ulrich Seidl, Malte Sebastian Depping, Bram Stieltjes, Klaus Maier-Hein, Robert Christian Wolf
• E-Jahr: 2019
• Jahr: 3 July 2019
• Umfang: 11 S.
• Fussnoten: Gesehen am 21.01.2020
• Titel Quelle: Enthalten in: European neuropsychopharmacology
• Ort Quelle: Amsterdam : Elsevier, 1990
• Jahr Quelle: 2019
• Band/Heft Quelle: 29(2019), 8, Seite 925-935
• ISSN Quelle: 1873-7862
• DOI: doi:10.1016/j.euroneuro.2019.06.002
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Default mode network
• Sach-SW: Functional connectivity
• Sach-SW: Functional magnetic resonance imaging
• Sach-SW: Medial prefrontal cortex
• Sach-SW: Salience network
• K10plus-PPN: 1687937052

Abstract

Major depressive disorder (MDD) and schizophrenia (SCZ) share neurobiological and clinical commonalities. Altered functional connectivity of large-scale brain networks has been associated with both disorders. Electroconvulsive therapy (ECT) has proven to be an effective treatment in severe forms of MDD and SCZ. However, the role of ECT on the modulation of the dynamics of brain networks is still unknown. In this study, we used resting state functional magnetic resonance imaging (rs-fMRI) to investigate functional connectivity in 16 pharmacoresistant patients with SCZ or MDD and a matched group of normal controls. Patients were scanned before and after right-sided unilateral ECT. Group spatial independent component analysis was carried out with a multiple analysis of covariance (MANCOVA) approach to estimate the effects of ECT treatment on intrinsic components (INs). Functional network connectivity (FNC) was calculated between pairs of INs. Patients had reduced connectivity within a striato-thalamic network in the thalamus as well as increased low frequency oscillations in a striatal network. ECT reduced low frequency oscillations (LFOs) on a striatal network along with increasing functional connectivity in the medial prefrontal cortex within the DMN. Following ECT treatment, the FNC of the executive network was reduced with the DMN and increased with the salience network, respectively. Our findings suggest transnosological effects of ECT on the connectivity of large-scale networks as well as at the level of their interplay. Furthermore, they support a transnosological approach for the investigation not only of the neural correlates of the disease but also of the brain mechanism of treatment of mental disorders.