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Verfasst von:Sykora, Marek [VerfasserIn]   i
 Siarnik, Pavel [VerfasserIn]   i
 Szabo, Jozef [VerfasserIn]   i
 Turcani, Peter [VerfasserIn]   i
 Krebs, Stefan [VerfasserIn]   i
 Lang, Wilfried [VerfasserIn]   i
 Jakubicek, Stanislava [VerfasserIn]   i
 Czosnyka, Marek [VerfasserIn]   i
 Smielewski, Peter [VerfasserIn]   i
Titel:Baroreflex sensitivity is associated with post-stroke infections
Titelzusatz:an open, prospective study
Verf.angabe:Marek Sykora, Pavel Siarnik, Jozef Szabo, Peter Turcani, Stefan Krebs, Wilfried Lang, Stanislava Jakubicek, Marek Czosnyka, Peter Smielewski
E-Jahr:2019
Jahr:03 September 2019
Fussnoten:Gesehen am 21.01.2020
Titel Quelle:Enthalten in: Journal of the neurological sciences
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1964
Jahr Quelle:2019
Band/Heft Quelle:406(2019) Artikel-Nummer 116450, 5 Seiten
ISSN Quelle:1878-5883
Abstract:Background and purpose - Autonomic nervous system (ANS) seems to play an important role in the post-stroke immunosuppression syndrome with increased susceptibility to infections. The aim of this study was to investigate if ANS activity measured at admission is associated with post-stroke infections. - Methods - We prospectively analyzed patients with acute ischemic stroke. ANS was measured using the cross-correlational baroreflex sensitivity (BRS) at admission. The occurrence and cause of in-hospital infections was assessed based on the clinical and laboratory examination. Demographic and clinical variables including initial stroke severity, dysphagia, procedures as nasogastric tubes, central venous and urinary catheters and mechanical ventilation were included in the analysis. - Results - We included 161 patients with ischemic stroke, of those 49 (30.4%) developed a nosocomial infection during the first 7days of hospital stay. Patients with infections had significantly lower BRS (median 3 vs 5ms/mmHg, p<.001) higher initial NIHSS (median 15 vs 5, p<.001), had more often non-lacunar etiology and underwent more invasive procedures. In the multivariable regression model decreased BRS (adjusted OR 1.21, 95% CI 1.03-1.41, p=.02), admission NIHSS (adjusted OR 1.10, 95% CI 1.02-1.19, p=.02) and invasive procedures (adjusted OR 1.46, 95% CI 1.03-2.06, p=.03) were independently associated with infection after ischemic stroke. - Conclusions - Decreased BRS was independently associated with infections after ischemic stroke. Autonomic shift may play an important role in increased susceptibility to infections after stroke. The possible diagnostic and therapeutic relevance of this finding deserves further research.
DOI:doi:10.1016/j.jns.2019.116450
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.jns.2019.116450
 Volltext: http://www.sciencedirect.com/science/article/pii/S0022510X1930382X
 DOI: https://doi.org/10.1016/j.jns.2019.116450
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Autonomic
 Baroreflex
 Infection
 Pneumonia
 Stroke
K10plus-PPN:1687938148
Verknüpfungen:→ Zeitschrift

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