A hypothesis of radioresistance and cell-survival curve shape based on cell-cycle progression and damage tolerance

• Verfasst von: Herskind, Carsten [VerfasserIn]
• Verfasst von: Liu, Qi [VerfasserIn]
• Verfasst von: Liu, Xiaolei [VerfasserIn]
• Verfasst von: Zhang, Yingying [VerfasserIn]
• Verfasst von: Ma, Lin [VerfasserIn]
• Verfasst von: Angelie, Elsa [VerfasserIn]
• Verfasst von: Ma, Hui Hui [VerfasserIn]
• Verfasst von: Liu, Junqi [VerfasserIn]
• Verfasst von: Giordano, Frank Anton [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Verfasst von: Veldwijk, Marlon Romano [VerfasserIn]
• Titel: A hypothesis of radioresistance and cell-survival curve shape based on cell-cycle progression and damage tolerance
• Verf.angabe: Carsten Herskind, Qi Liu, Xiaolei Liu, Yingying Zhang, Lin Ma, Elsa Angelie, Hui Hui Ma, Junqi Liu, Frank A. Giordano, Frederik Wenz and Marlon R. Veldwijk
• Jahr: 2019
• Umfang: 4 S.
• Fussnoten: Advance Access publication 11 December 2018 ; Gesehen am 21.01.2020
• Titel Quelle: Enthalten in: Radiation protection dosimetry
• Ort Quelle: Ashford : [Verlag nicht ermittelbar], 1981
• Jahr Quelle: 2019
• Band/Heft Quelle: 183(2019), 1/2, Seite 107-110
• ISSN Quelle: 1742-3406
• DOI: doi:10.1093/rpd/ncy247
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1687972192

Abstract

Exponential survival curves of early-passage humanfibroblasts challenge classic biophysical models of cell inactivation. Thus,X-ray doses of 2–4 Gy inactivate normal, human skinfibroblasts in spite of negligible residual double-strand breaks. By con-trast, radioresistant p53-mutant U251 glioblastoma cells proliferate in spite of residual damage. Similarly, p53 wildtype TK6lymphoblastoid cells show exponential survival curves while the related p53-mutant WTK1 cell line continued to proliferateand showed a shouldered survival curve. Here, we propose a model in which the radioresistant shoulder region is due to toler-ance to certain types or amounts of residual damage that would otherwise inactivate normal cells. Thus, the steeper initialslope and absence of a shoulder in the survival curve of normal cells may not imply a higher number of residual lesions butrather non-tolerance to these lesions.