Status: Bibliographieeintrag
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| Verfasst von: | Arnold, Andrea [VerfasserIn]  |
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| | Daum, S. [VerfasserIn] |
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| | Winterfeld, Moritz von [VerfasserIn] |
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| | Berg, E. [VerfasserIn] |
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| | Hummel, M. [VerfasserIn] |
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| | Horst, D. [VerfasserIn] |
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| | Rau, B. [VerfasserIn] |
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| | Stein, U. [VerfasserIn] |
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| | Treese, C. [VerfasserIn] |
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| Titel: | Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry |
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| Verf.angabe: | A. Arnold, S. Daum, M. von Winterfeld, E. Berg, M. Hummel, D. Horst, B. Rau, U. Stein, C. Treese |
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| E-Jahr: | 2019 |
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| Jahr: | 19 September 2019 |
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| Fussnoten: | Gesehen am 22.01.2020 |
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| Titel Quelle: | Enthalten in: Pathology, research and practice |
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| Ort Quelle: | München : Elsevier, 1978 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 215(2019,11) Artikel-Nummer 152662, 3 Seiten |
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| ISSN Quelle: | 1618-0631 |
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| Abstract: | Small molecule inhibitors such as Larotrectinib have been recently approved in the treatment of patients with fusions of the neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) genes 1-3. These genomic rearrangements have been reported across different tumor subtypes with a high prevalence in rare tumors. However, in gastric and esophageal adenocarcinoma (AGE) NTRK fusions have also been described in a subset of Asian patients. In order to study the prevalence of this alteration in Caucasian patients with AGE we performed immunohistochemistry for pan-NTRK in 438 formalin-fixed paraffin embedded (FFPE) tumor samples. While we found NTRK expression in gastric glands and tumor adjacent nerve tissue, we did not detect this marker in the tumor compartment. Based on our findings NTRK fusions do not seem to play a role in the molecularpathology of Caucasian AEG patients, so that other treatment options are required. |
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| DOI: | doi:10.1016/j.prp.2019.152662 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.prp.2019.152662 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0344033819317297 |
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| | DOI: https://doi.org/10.1016/j.prp.2019.152662 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Gastric and esophageal adenocarcinoma (AGE) |
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| | Larotrectinib |
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| | Neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) gene fusion |
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| K10plus-PPN: | 1688009523 |
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| Verknüpfungen: | → Zeitschrift |
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Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry / Arnold, Andrea [VerfasserIn]; 19 September 2019 (Online-Ressource)
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