Risk factors and survival of patients with permanent pacemaker implantation after heart transplantation

• Verfasst von: Rivinius, Rasmus [VerfasserIn]
• Verfasst von: Helmschrott, Matthias [VerfasserIn]
• Verfasst von: Rahm, Ann-Kathrin [VerfasserIn]
• Verfasst von: Darche, Fabrice Fernand [VerfasserIn]
• Verfasst von: Thomas, Dierk [VerfasserIn]
• Verfasst von: Bruckner, Thomas [VerfasserIn]
• Verfasst von: Dösch, Andreas [VerfasserIn]
• Verfasst von: Ehlermann, Philipp [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Zitron, Edgar [VerfasserIn]
• Titel: Risk factors and survival of patients with permanent pacemaker implantation after heart transplantation
• Verf.angabe: Rasmus Rivinius, Matthias Helmschrott, Ann-Kathrin Rahm, Fabrice F. Darche, Dierk Thomas, Tom Bruckner, Andreas O. Doesch, Philipp Ehlermann, Hugo A. Katus, Edgar Zitron
• Jahr: 2019
• Umfang: 13 S.
• Fussnoten: Gesehen am 22.01.2020
• Titel Quelle: Enthalten in: Journal of thoracic disease
• Ort Quelle: Hong Kong : Pioneer Bioscience Publ., 2009
• Jahr Quelle: 2019
• Band/Heft Quelle: 11(2019), 12, Seite 5440-5452
• ISSN Quelle: 2077-6624
• DOI: doi:10.21037/jtd.2019.11.45
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1688024891
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Background: Permanent pacemaker (PPM) implantation after heart transplantation (HTX) may be required due to severe bradycardia. The aim of this study was to investigate the risk factors, indications, perioperative outcomes and complications of PPM implantation after HTX as well as the underlying effect on post-transplant mortality including causes of death. - Methods: This registry study included 621 patients receiving HTX at Heidelberg Heart Center between 1989 and 2018. Patients were stratified by PPM implantation after HTX. Data analysis of risk factors for PPM implantation included donor and recipient demographics, post-transplant medication, mortality, and causes of death. - Results: Thirty-six patients (5.8%) received PPM implantation after HTX, 12 (33.3%) with early PPM and 24 (66.7%) with late PPM. Indications for PPM implantation after HTX included sinus node dysfunction (SND) (n=15; 41.7%) and atrioventricular block (AVB) (n=21; 58.3%). Multivariate analysis revealed recipient body mass index (BMI) [hazard ratio (HR): 1.10; confidence interval (CI): 1.01-1.21; P=0.03], donor age (HR: 1.07; CI: 1.03-1.10; P Conclusions: Multivariate risk factors for PPM implantation after HTX include recipient BMI, donor age, and biatrial HTX. Early PPM implantation after HTX is associated with increased 5-year post-transplant mortality due to infection.