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Status: Bibliographieeintrag

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Verfasst von:Butt, Julia [VerfasserIn]   i
 Pawlita, Michael [VerfasserIn]   i
 Kaaks, Rudolf [VerfasserIn]   i
 Kühn, Tilman [VerfasserIn]   i
 Waterboer, Tim [VerfasserIn]   i
Titel:Antibody responses to fusobacterium nucleatum proteins in prediagnostic blood samples are not associated with risk of developing colorectal cancer
Verf.angabe:Julia Butt, Mazda Jenab, Michael Pawlita, Kim Overvad, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Franck Carbonnel, Francesca Romana Mancini, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Domenico Palli, Valeria Maria Pala, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Bas Bueno-de-Mesquita, Carla H. van Gils, Roel C.H. Vermeulen, Elisabete Weiderpass, José Ramón Quirós, Eric Jeffrey Duell, Maria-Jose Sánchez, Miren Dorronsoro, José María Huerta, Eva Ardanaz, Bethany Van Guelpen, Sophia Harlid, Aurora Perez-Cornago, Marc J. Gunter, Neil Murphy, Heinz Freisling, Dagfinn Aune, Tim Waterboer, and David J. Hughes
E-Jahr:2019
Jahr:September 3, 2019
Umfang:4 S.
Fussnoten:Gesehen am 24.01.2020
Titel Quelle:Enthalten in: Cancer epidemiology, biomarkers & prevention
Ort Quelle:Philadelphia, Pa. : AACR, 1991
Jahr Quelle:2019
Band/Heft Quelle:28(2019), 9, Seite 1552-1555
ISSN Quelle:1538-7755
Abstract:Background: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort. - Methods: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). - Results: We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62-1.06). - Conclusions: Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk. - Impact: Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings.
DOI:doi:10.1158/1055-9965.EPI-19-0313
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1158/1055-9965.EPI-19-0313
 Verlag: https://cebp.aacrjournals.org/content/28/9/1552
 DOI: https://doi.org/10.1158/1055-9965.EPI-19-0313
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1688456600
Verknüpfungen:→ Zeitschrift

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