New directions in the treatment of glioblastoma

• Verfasst von: Reitman, Zachary J. [VerfasserIn]
• Verfasst von: Winkler, Frank [VerfasserIn]
• Verfasst von: Elia, Andrew [VerfasserIn]
• Titel: New directions in the treatment of glioblastoma
• Verf.angabe: Zachary J. Reitman, Frank Winkler, Andrew E. H. Elia
• E-Jahr: 2018
• Jahr: 16. März 2018
• Umfang: 10 S.
• Fussnoten: Gesehen am 27.01.2020
• Titel Quelle: Enthalten in: Seminars in neurology
• Ort Quelle: New York, NY : Thieme Medical Publ., 1981
• Jahr Quelle: 2018
• Band/Heft Quelle: 38(2018), 01, Seite 050-061
• ISSN Quelle: 1098-9021
• DOI: doi:10.1055/s-0038-1623534
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1688599088

Abstract

<p>Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. The current standard of care for GBM is maximal resection followed by postoperative radiation with concomitant and adjuvant temozolomide. Despite this multimodality treatment, the median survival for GBM remains marginally better than 1 year. In the past decade, genome-wide analyses have uncovered new molecular features of GBM that have refined its classification and provided new insights into the molecular basis for GBM pathogenesis. Here, we review these molecular features and discuss major clinical trials that have recently defined the field. We describe genetic alterations in isocitrate dehydrogenase, ATRX, the telomerase promoter, and histone H3 variants that promote GBM tumorigenesis and have altered GBM categorization. We also discuss intratumoral genetic heterogeneity as one explanation for therapeutic failures and explain how ultra-long extensions of glioma cells, called tumor microtubes, mediate therapeutic resistance. These findings provide new insights into GBM biology and offer hope for the development of next-generation therapies.</p>