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Verfasst von:Xu, Linrui [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
Titel:A higher rate of pulmonary fungal infection in chronic obstructive pulmonary disease patients with influenza in a large tertiary hospital
Verf.angabe:Linrui Xu, Bojiang Chen, Faping Wang, Chuanqi Wei, Huan Liu, Jia Liu, Felix J.F. Herth, Fengming Luo
E-Jahr:2019
Jahr:July 22, 2019
Umfang:10 S.
Teil:volume:98
 year:2019
 number:5
 pages:391-400
 extent:10
Fussnoten:Gesehen am 30.01.2020
Titel Quelle:Enthalten in: Respiration
Ort Quelle:Basel : Karger, 1944
Jahr Quelle:2019
Band/Heft Quelle:98(2019), 5, Seite 391-400
ISSN Quelle:1423-0356
Abstract:<b><i>Background:</i></b> Influenza is considered a self-limiting disease. However, in patients with chronic obstructive pulmonary disease (COPD), it may result in serious outcomes during the flu season. <b><i>Objectives:</i></b> The aims of this retrospective study were to explore the characteristics of hospitalized patients with COPD complicated by influenza and determine the factors affecting the prognosis of these patients. <b><i>Method:</i></b> Demographic and clinical data were collected for 278 patients totally from the West China Hospital between January 1, 2016 and February 28, 2018. <b><i>Results:</i></b> Among the patients with influenza, the positive fungal culture rate, and the rates of antifungal drug and systemic corticosteroids use were higher for those with COPD than for those without COPD. Respiratory failure was more common in patients with influenza and COPD than in patients with influenza only, while the proportion of severe cases was higher among the former than among the latter. Among the patients with COPD, the positive fungal culture rate, particularly for <i>Aspergillus</i>, and the rate of systemic corticosteroids use were higher for those with influenza than for those without influenza. Multivariate analysis revealed that a COPD history of &#x3e;20 years and smoking for &#x3e;20 pack-years were independent factors for susceptibility of COPD patients to influenza. <b><i>Conclusions:</i></b> <i>Aspergillus</i> infection seems to be more common in patients with influenza and COPD. In addition, COPD complicated by influenza during the seasonal outbreak can easily progress to a severe disease state. Heavy smokers and patients with a prolonged COPD history are more likely to be infected by influenza.
DOI:doi:10.1159/000501410
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1159/000501410
 Volltext: https://www.karger.com/Article/FullText/501410
 DOI: https://doi.org/10.1159/000501410
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1688641815
Verknüpfungen:→ Zeitschrift

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