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Verfasst von:Meyer, Mathias [VerfasserIn]   i
Titel:Reproducibility of CT radiomic features within the same patient
Titelzusatz:influence of radiation dose and CT reconstruction settings
Verf.angabe:Mathias Meyer, MD, James Ronald, MD, Federica Vernuccio, MD, Rendon C. Nelson, MD, Juan Carlos Ramirez-Giraldo, PhD, Justin Solomon, PhD, Bhavik N. Patel, MD, MBA, Ehsan Samei, PhD, Daniele Marin, MD
E-Jahr:2019
Jahr:Oct 1 2019
Umfang:9 S.
Fussnoten:Gesehen am 06.02.2020
Titel Quelle:Enthalten in: Radiology
Ort Quelle:Oak Brook, Ill. : Soc., 1923
Jahr Quelle:2019
Band/Heft Quelle:293(2019), 3, Seite 583-591
ISSN Quelle:1527-1315
Abstract:BackgroundResults of recent phantom studies show that variation in CT acquisition parameters and reconstruction techniques may make radiomic features largely nonreproduceable and of limited use for prognostic clinical studies.PurposeTo investigate the effect of CT radiation dose and reconstruction settings on the reproducibility of radiomic features, as well as to identify correction factors for mitigating these sources of variability.Materials and MethodsThis was a secondary analysis of a prospective study of metastatic liver lesions in patients who underwent staging with single-energy dual-source contrast material-enhanced staging CT between September 2011 and April 2012. Technique parameters were altered, resulting in 28 CT data sets per patient that included different dose levels, section thicknesses, kernels, and reconstruction algorithm settings. By using a training data set (n = 76), reproducible intensity, shape, and texture radiomic features (reproducibility threshold, R2 ≥ 0.95) were selected and correction factors were calculated by using a linear model to convert each radiomic feature to its estimated value in a reference technique. By using a test data set (n = 75), the reproducibility of hierarchical clustering based on 106 radiomic features measured with different CT techniques was assessed.ResultsData in 78 patients (mean age, 60 years ± 10; 33 women) with 151 liver lesions were included. The percentage of radiomic features deemed reproducible for any variation of the different technical parameters was 11% (12 of 106). Of all technical parameters, reconstructed section thickness had the largest impact on the reproducibility of radiomic features (12.3% [13 of 106]) if only one technical parameter was changed while all other technical parameters were kept constant. The results of the hierarchical cluster analysis showed improved clustering reproducibility when reproducible radiomic features with dedicated correction factors were used (ρ = 0.39-0.71 vs ρ = 0.14-0.47).ConclusionMost radiomic features are highly affected by CT acquisition and reconstruction settings, to the point of being nonreproducible. Selecting reproducible radiomic features along with study-specific correction factors offers improved clustering reproducibility.© RSNA, 2019Online supplemental material is available for this article.See also the editorial by Sosna in this issue.
DOI:doi:10.1148/radiol.2019190928
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1148/radiol.2019190928
 Volltext: https://pubs.rsna.org/doi/10.1148/radiol.2019190928
 DOI: https://doi.org/10.1148/radiol.2019190928
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1688645837
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