Risk factors for early viral infections after liver transplantation

• Verfasst von: Busch, Cornelius [VerfasserIn]
• Verfasst von: Siegler, Benedikt Hermann [VerfasserIn]
• Verfasst von: Werle, Heike [VerfasserIn]
• Verfasst von: Lichtenstern, Christoph [VerfasserIn]
• Verfasst von: Bruckner, Thomas [VerfasserIn]
• Verfasst von: Heininger, Alexandra [VerfasserIn]
• Verfasst von: Mehrabi, Arianeb [VerfasserIn]
• Verfasst von: Weiss, Karl Heinz [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Verfasst von: Hochreiter, Marcel [VerfasserIn]
• Titel: Risk factors for early viral infections after liver transplantation
• Verf.angabe: Cornelius Johannes Busch, Benedikt Hermann Siegler, Heike Werle, Christoph Lichtenstern, Thomas Bruckner, Alexandra Heininger, Arianeb Mehrabi, Karl Heinz Weiss, Markus Alexander Weigand, Marcel Hochreiter
• E-Jahr: 2018
• Jahr: 25 April 2018
• Umfang: 11 S.
• Fussnoten: Gesehen am 04.02.2020
• Titel Quelle: Enthalten in: Langenbeck's archives of surgery
• Ort Quelle: Berlin : Springer, 1948
• Jahr Quelle: 2018
• Band/Heft Quelle: 403(2018), 4, Seite 509-519
• ISSN Quelle: 1435-2451
• DOI: doi:10.1007/s00423-018-1672-3
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1689235845

Abstract

Purpose: Viral infections represent a serious threat for patients after liver transplantation (LT). The identification of risk factorsduring the early post-transplant period might help to improve prevention of viral infections after LT. Methods: Between 2004 and 2010, 530 adult patients underwent LTat a large university hospital serving a metropolitan region inEurope. This retrospective single-centre study analysed putative risk factors for early viral infections with herpes simplex virus-1(HSV-1), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), hepatitis A/B/C (HAV/HBV/HCV) and cytomegalovirus(CMV) in the first 3 months after LT. Results: The final analysis included 501 patients of whom 126 (25.1%) had documented viral infections after LT. No significantdifferences could be detected between patients with or without viral infections concerning 30- and 90-day mortality. Risk factorsin the early post-transplant period identified by multivariate analysis included female gender (CMV, HSV-1), the post-operativeneed for continuous veno-venous hemofiltration (CMV), septic shock (CMV), detection of fungi (CMV) and the intraoperativeamount of transfused blood (EBV). Conclusions: Enhanced vigilance regarding opportunistic infections is crucial in the management of this high-risk population ofimmunocompromised patients. In particular, attention should be paid to avoidable conditions that increase the risk of renalreplacement therapies in the post-LT setting, especially among women.Trial registration: DRKS00010672 on German Clinical Trial Register