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Status: Bibliographieeintrag

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Verfasst von:Zimmer, Philipp [VerfasserIn]   i
 Schmidt, Martina [VerfasserIn]   i
 Prentzell, Mirja Tamara [VerfasserIn]   i
 Berdel, Bianca [VerfasserIn]   i
 Wiskemann, Joachim [VerfasserIn]   i
 Kellner, Karl Heinz [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Ulrich, Cornelia [VerfasserIn]   i
 Opitz, Christiane A. [VerfasserIn]   i
 Steindorf, Karen [VerfasserIn]   i
Titel:Resistance exercise reduces kynurenine pathway metabolites in breast cancer patients undergoing radiotherapy
Verf.angabe:Philipp Zimmer, Martina E. Schmidt, Mirja Tamara Prentzell, Bianca Berdel, Joachim Wiskemann, Karl Heinz Kellner, Jürgen Debus, Cornelia Ulrich, Christiane A. Opitz and Karen Steindorf
E-Jahr:2019
Jahr:25 September 2019
Umfang:11 S.
Fussnoten:Gesehen am 04.02.2020
Titel Quelle:Enthalten in: Frontiers in oncology
Ort Quelle:Lausanne : Frontiers Media, 2011
Jahr Quelle:2019
Band/Heft Quelle:9(2019) Artikel-Nummer 962, 11 Seiten
ISSN Quelle:2234-943X
Abstract:Purpose: Evidence from preclinical studies and trials in healthy volunteers suggests that exercise may modulate the levels of tryptophan (TRP) metabolites along the kynurenine (KYN) pathway. As KYN and downstream KYN metabolites are known to promote cancer progression by inhibiting anti-tumor immune responses and by promoting the motility of cancer cells, we investigated if resistance exercise can also control the levels of KYN pathway metabolites in breast cancer patients undergoing radiotherapy (NCT01468766). Patients and Methods: Chemotherapy-naïve breast cancer patients (n = 96) were either randomized to an exercise/intervention group (IG) or a control group (CG). The IG participated in a 12-week supervised progressive resistance exercise program twice a week, whereas the CG received a supervised relaxation program. Serum levels of TRP and KYN as well as urine levels of kynurenic acid (KYNA) and neurotoxic quinolinic acid (QUINA) were assessed before (t0), after radiotherapy, and mid-term of the exercise intervention (t1) and after the exercise intervention (t2). Additionally, 24 healthy women (HIG) participated in the exercise program to investigate potential differences in its effects on KYN metabolites in comparison to the breast cancer patients. Results: At baseline (t0) the breast cancer patients showed a significantly elevated serum KYN/TRP ratio and urine QUINA/KYNA ratio, as well as increased urine QUINA levels in comparison to the healthy women. In response to exercise the healthy women and the breast cancer patients differed significantly in the levels of urine QUINA and the QUINA/KYNA ratio. Most importantly, serum KYN levels and the KYN/TRP ratio were significantly reduced in exercising patients (IG) compared to non-exercising patients (CG) both at t1 and t2. Conclusion: Resistance exercise may represent a potent non-pharmacological avenue to counteract an activation of the KYN pathway in breast cancer patients undergoing radiotherapy.
DOI:doi:10.3389/fonc.2019.00962
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.3389/fonc.2019.00962
 DOI: https://doi.org/10.3389/fonc.2019.00962
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cancer
 exercise
 kynurenic acid
 kynurenine
 physical activity
 quinolinic acid
 tryptophan
K10plus-PPN:1689237074
Verknüpfungen:→ Zeitschrift

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