| |  Online-Ressource |
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| Verfasst von: | Buschle, Lukas R. [VerfasserIn]  |
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| | Ziener, Christian H. [VerfasserIn] |
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| | Zhang, Ke [VerfasserIn] |
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| | Sturm, Volker Jörg Friedrich [VerfasserIn] |
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| | Kampf, Thomas [VerfasserIn] |
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| | Hahn, Artur [VerfasserIn] |
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| | Solecki, Gergely [VerfasserIn] |
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| | Winkler, Frank [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Heiland, Sabine [VerfasserIn] |
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| | Schlemmer, Heinz-Peter [VerfasserIn] |
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| | Kurz, Felix T. [VerfasserIn] |
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| Titel: | Vessel radius mapping in an extended model of transverse relaxation |
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| Verf.angabe: | Lukas Reinhold Buschle, Christian H. Ziener, Ke Zhang, Volker J.F. Sturm, Thomas Kampf, Artur Hahn, Gergely Solecki, Frank Winkler, Martin Bendszus, Sabine Heiland, Heinz-Peter Schlemmer, Felix T. Kurz |
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| E-Jahr: | 2018 |
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| Jahr: | 24 February 2018 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 04.02.2020 |
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| Titel Quelle: | Enthalten in: Magnetic resonance materials in physics, biology and medicine |
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| Ort Quelle: | Heidelberg : Springer, 1993 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 31(2018), 4, Seite 531-551 |
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| ISSN Quelle: | 1352-8661 |
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| Abstract: | Objectives: Spin dephasing of the local magnetization in blood vessel networks can be described in the static dephasing regime (where diffusion effects may be ignored) by the established model of Yablonskiy and Haacke. However, for small capillary radii, diffusion phenomena for spin-bearing particles are not negligible. Material and methods: In this work, we include diffusion effects for a set of randomly distributed capillaries and provide analytical expressions for the transverse relaxation times T2* and T2 in the strong collision approximation and the Gauss-ian approximation that relate MR signal properties with microstructural parameters such as the mean local capillary radius. Results: Theoretical results are numerically validated with random walk simulations and are used to calculate capillary radius distribution maps for glioblastoma mouse brains at 9.4 T. For representative tumor regions, the capillary maps reveal a relative increase of mean radius for tumor tissue towards healthy brain tissue of 128±23% (p < 0.001). Conclusion: The presented method may be used to quantify angiogenesis or the effects of antiangiogenic therapy in tumors whose growth is associated with significant microvascular changes |
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| DOI: | doi:10.1007/s10334-018-0677-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s10334-018-0677-9 |
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| | DOI: https://doi.org/10.1007/s10334-018-0677-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1689242949 |
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| Verknüpfungen: | → Zeitschrift |
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Vessel radius mapping in an extended model of transverse relaxation / Buschle, Lukas R. [VerfasserIn]; 24 February 2018 (Online-Ressource)
