Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines

• Verfasst von: Pavel, Ileana-Alexandra [VerfasserIn]
• Verfasst von: Amadei, Federico [VerfasserIn]
• Verfasst von: Kaufmann, Stefan [VerfasserIn]
• Verfasst von: Tanaka, Motomu [VerfasserIn]
• Titel: Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines
• Verf.angabe: Ileana-Alexandra Pavel, Maxime Girardon, Sarah El Hajj, Stéphane Parant, Federico Amadei, Stefan Kaufmann, Motomu Tanaka, Vanessa Fierro, Alain Celzard, Nadia Canilho and Andreea Pasc
• E-Jahr: 2018
• Jahr: [2018]
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 10.02.2020
• Titel Quelle: Enthalten in: Journal of materials chemistry / B
• Ort Quelle: London [u.a.] : RSC, 2013
• Jahr Quelle: 2018
• Band/Heft Quelle: 6(2018), 35, Seite 5633-5639
• ISSN Quelle: 2050-7518
• DOI: doi:10.1039/C8TB01114A
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1689727357

Abstract

β-Galactosidase has been drawing increasing attention for the treatment of lactose intolerance, but its delivery has been impeded by degradation under gastric conditions. We have demonstrated that the coating of mesoporous silica microparticles (diameter ≈ 9 µm, pore size ≈ 25 nm) with dioleoylphosphatidylcholine membranes significantly improved the loading capability and protected the enzymes from the loss of function under simulated gastric conditions. Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to the release of functional β-galactosidase. The coating of mesoporous silica nanoparticles with a single phospholipid bilayer opens up a large potential towards the controlled release of orally administrated drugs or enzymes to the intestines.