| |  Online-Ressource |
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| Verfasst von: | Flechsig, Paul [VerfasserIn]  |
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| | Kratochwil, Clemens [VerfasserIn] |
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| | Warth, Arne [VerfasserIn] |
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| | Rath, Daniel [VerfasserIn] |
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| | Eichwald, Viktoria [VerfasserIn] |
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| | Huber, Peter E. [VerfasserIn] |
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| | Kauczor, Hans-Ulrich [VerfasserIn] |
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| | Haberkorn, Uwe [VerfasserIn] |
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| | Giesel, Frederik L. [VerfasserIn] |
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| Titel: | A comparison of microCT and microPET for evaluating lymph node metastasis in a rat model |
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| Verf.angabe: | Paul Flechsig, Clemens Kratochwil, Arne Warth, Daniel Rath, Viktoria Eichwald, Peter E. Huber, Hans-Ulrich Kauczor, Uwe Haberkorn, Frederik L. Giesel |
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| Jahr: | 2016 |
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| Jahr des Originals: | 2015 |
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| Umfang: | 6 S. |
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| Fussnoten: | Published Online: 2 September 2015 ; Gesehen am 11.02.2020 |
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| Titel Quelle: | Enthalten in: Molecular imaging & biology |
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| Ort Quelle: | Cham : Springer Nature Switzerland, 2002 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 18(2016), 2, Seite 243-248 |
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| ISSN Quelle: | 1860-2002 |
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| Abstract: | PurposeThe demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the role of microPET and microCT for mediastinal lymph node staging in an orthotopic lung cancer model in rats.ProceduresHuman lung cancer cells (NCI-H460) were injected transthoracically in nude rats (NIH-RNU). After 2 weeks of tumour growth, animals underwent multiphase contrast-enhanced microCT using ExiTron nano 12000 as a contrast agent and dynamic microPET using the tracer 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG). Thereafter, animals were sacrificed for histological analysis.ResultsLate phase micro X-ray computed tomography (microCT) revealed the best delineation of lymph node metastases, as compared to earlier scans. In terms of an increased [18F]FDG uptake over time, dynamic micro positron emission tomography (microPET) delineated lymph node metastases and enabled metabolic examinations of the induced lung cancer metastases.ConclusionThe combination of contrast-enhanced microCT and dynamic microPET is feasible in rats for the visualization of mediastinal lymph node metastases. |
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| DOI: | doi:10.1007/s11307-015-0890-0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1007/s11307-015-0890-0 |
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| | Volltext: https://link.springer.com/article/10.1007%2Fs11307-015-0890-0 |
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| | DOI: https://doi.org/10.1007/s11307-015-0890-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Computed tomography |
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| | Lung cancer |
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| | Orthotopic lung cancer model |
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| K10plus-PPN: | 168978122X |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ comparison of microCT and microPET for evaluating lymph node metastasis in a rat model / Flechsig, Paul [VerfasserIn]; 2016 (Online-Ressource)
