Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III

• Verfasst von: Bodem, Jens [VerfasserIn]
• Verfasst von: Schaal, Carolin [VerfasserIn]
• Verfasst von: Kargus, Steffen [VerfasserIn]
• Verfasst von: Saure, Daniel [VerfasserIn]
• Verfasst von: Mertens, Christian [VerfasserIn]
• Verfasst von: Engel, Michael [VerfasserIn]
• Verfasst von: Hoffmann, Jürgen [VerfasserIn]
• Verfasst von: Freudlsperger, Christian [VerfasserIn]
• Titel: Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III
• Verf.angabe: Jens Philipp Bodem, MD, DDS, Carolin Schaal, DDS, Steffen Kargus, MD, DDS, Daniel Saure, PhD, Christian Mertens, DDS, Michael Engel, MD, DDS, Jürgen Hoffmann, MD, DDS, and Christian Freudlsperger, MD, DDS
• Jahr: 2016
• Umfang: 6 S.
• Fussnoten: Available online 1 December 2015 ; Gesehen am 11.02.2020
• Titel Quelle: Enthalten in: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontology
• Ort Quelle: Orlando, Fla. : Elsevier, 1979
• Jahr Quelle: 2016
• Band/Heft Quelle: 121(2016), 4, Seite 367-372
• ISSN Quelle: 1528-395X
• DOI: doi:10.1016/j.oooo.2015.10.033
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1689784822

Abstract

Objective - The value of surgery in advanced stages of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is still controversial. Hence, we evaluated the effect of surgical therapy in BRONJ stages II and III in combination with a standardized perioperative adjuvant treatment. - Study Design - We included 39 patients who presented with BRONJ in a total of 47 locations and stages II (n = 23) and III (n = 24). All patients had exclusively received a monthly intravenous application of zoledronic acid. Surgical therapy consisted of complete removal of the necrotic jaw, accompanied by a standardized perioperative adjuvant treatment including intravenous antibiotic prophylaxis, gastric feeding, and an antimicrobiologic mouth rinsing. - Results - Overall, 35 (74.5%) of the 47 BRONJ sites were treated successfully, with success defined as complete mucosal healing of the exposed jaw (n = 24) or as relative healing when surgical therapy downscaled BRONJ II or III to asymptomatic BRONJ stage I (n = 11). Interestingly, perioperative adjuvant treatment or bisphosphonate therapy parameters showed no statistical effect on the treatment outcome. - Conclusions - The results of the present study prove the effectiveness of surgical therapy for BRONJ stage II or III.