| |  Online-Ressource |
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| Verfasst von: | Chun, Hye-Jung E. [VerfasserIn]  |
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| | Johann, Pascal-David [VerfasserIn] |
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| | Zapatka, Marc [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| Titel: | Identification and analyses of extra-cranial and cranial rhabdoid tumor molecular subgroups reveal tumors with cytotoxic T cell infiltration |
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| Verf.angabe: | Hye-Jung E. Chun, Pascal D. Johann, Katy Milne, Marc Zapatka, Annette Buellesbach, Naveed Ishaque, Murat Iskar, Serap Erkek, Lisa Wei, Basile Tessier-Cloutier, Jake Lever, Emma Titmuss, James T. Topham, Reanne Bowlby, Eric Chuah, Karen L. Mungall, Yussanne Ma, Andrew J. Mungall, Richard A. Moore, Michael D. Taylor, Daniela S. Gerhard, Steven J. M. Jones, Andrey Korshunov, Manfred Gessler, Kornelius Kerl, Martin Hasselblatt, Michael C. Frühwald, Elizabeth J. Perlman, Brad H. Nelson, Stefan M. Pfister, Marco A. Marra, and Marcel Kool |
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| E-Jahr: | 2019 |
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| Jahr: | 7 November, 2019 |
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| Umfang: | 24 S. |
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| Fussnoten: | Gesehen am 05.08.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 29(2019), 8, Seite 2338-2354.e1-e7 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we analyze multi-omics data from 140 MRTs and 161 ATRTs. We detect similarities between the MYC subgroup of ATRTs (ATRT-MYC) and extra-cranial MRTs, including global DNA hypomethylation and overexpression of HOX genes and genes involved in mesenchymal development, distinguishing them from other ATRT subgroups that express neural-like features. We identify five DNA methylation subgroups associated with anatomical sites and SMARCB1 mutation patterns. Groups 1, 3, and 4 exhibit cytotoxic T cell infiltration and expression of immune checkpoint regulators, consistent with a potential role for immunotherapy in rhabdoid tumor patients. |
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| DOI: | doi:10.1016/j.celrep.2019.10.013 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2019.10.013 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124719313130 |
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| | DOI: https://doi.org/10.1016/j.celrep.2019.10.013 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | atypical teratoid rhabdoid tumor |
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| | cytotoxic T cell infiltration |
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| | dysregulation |
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| | genomic and epigenomic dysregulation |
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| | Malignant rhabdoid tumor |
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| | molecular subgroups |
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| | pediatric cancer |
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| | SMARCB1 |
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| | tumor-infiltrating immune cells |
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| K10plus-PPN: | 1689965681 |
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| Verknüpfungen: | → Zeitschrift |
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Identification and analyses of extra-cranial and cranial rhabdoid tumor molecular subgroups reveal tumors with cytotoxic T cell infiltration / Chun, Hye-Jung E. [VerfasserIn]; 7 November, 2019 (Online-Ressource)
