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Verfasst von:Wittekindt, Claus [VerfasserIn]   i
 Wagner, Steffen [VerfasserIn]   i
 Bushnak, Ayman [VerfasserIn]   i
 Prigge, Elena-Sophie [VerfasserIn]   i
 Knebel Doeberitz, Magnus von [VerfasserIn]   i
 Würdemann, Nora [VerfasserIn]   i
 Bernhardt, Katharina [VerfasserIn]   i
 Pons-Kühnemann, Jörn [VerfasserIn]   i
 Maulbecker-Armstrong, Catharina [VerfasserIn]   i
 Klussmann, Jens Peter [VerfasserIn]   i
Titel:Increasing incidence rates of oropharyngeal squamous cell carcinoma in Germany and significance of disease burden attributed to human papillomavirus
Verf.angabe:Claus Wittekindt, Steffen Wagner, Ayman Bushnak, Elena-Sophie Prigge, Magnus von Knebel Doeberitz, Nora Würdemann, Katharina Bernhardt, Jörn Pons-Kühnemann, Catharina Maulbecker-Armstrong, and Jens Peter Klussmann
E-Jahr:2019
Jahr: April 19, 2019
Umfang:8 S.
Fussnoten:Gesehen am 13.02.2020
Titel Quelle:Enthalten in: Cancer Prevention Research
Ort Quelle:Philadelphia, Pa. : AACR, 2008
Jahr Quelle:2019
Band/Heft Quelle:12(2019), 6, Seite 375-382
ISSN Quelle:1940-6215
Abstract:Increasing incidences of head and neck cancers and rising proportions of these associated with human papillomavirus (HPV), especially in the oropharynx, have been reported in international studies. So far, the trends and contribution of HPV to the number of newly diagnosed cases of oropharyngeal squamous cell carcinomas (OPSCC) in Germany are uncertain. We investigated HPV association and incidence rates in a cohort of consecutively included patients with OPSCC in Giessen 2000-2017, and compared our results with regional (Giessen and the federal state of Hesse), national (Germany), and international (United States) databases. Regional data show a significant increase in the overall incidence rates of oropharyngeal cancers and in the incidence of HPV-associated cancers of the subsites tonsils and oropharynx, whereas other oropharyngeal subsites show no significant change. Analysis of national databases shows a significant incidence increase in Germany and in the United States. The rise in incidence is predominantly attributable to male patients in the US population, whereas in Germany rising OPSCC incidence is more associated with females. There is a significant elevation of OPSCC incidence rates in Germany, which corresponds to the recognized incidence increase of HPV-related oropharyngeal cancers based on experimental data from consecutively included patients of our cohort. Our investigation shows different patterns of this increase in Germany and in the United States, which demonstrates spatial heterogeneity and the need for population-based investigations regarding the role of HPV in oropharyngeal cancer.
DOI:doi:10.1158/1940-6207.CAPR-19-0098
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1158/1940-6207.CAPR-19-0098
 Volltext: https://cancerpreventionresearch.aacrjournals.org/content/12/6/375
 DOI: https://doi.org/10.1158/1940-6207.CAPR-19-0098
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1689987308
Verknüpfungen:→ Zeitschrift

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