| |  Online-Ressource |
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| Verfasst von: | Chennupati, Ramesh [VerfasserIn]  |
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| | Wirth, Angela [VerfasserIn] |
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| | Favre, Julie [VerfasserIn] |
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| | Li, Rui [VerfasserIn] |
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| | Bonnavion, Rémy [VerfasserIn] |
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| | Jin, Young-June [VerfasserIn] |
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| | Wietelmann, Astrid [VerfasserIn] |
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| | Schweda, Frank [VerfasserIn] |
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| | Wettschureck, Nina [VerfasserIn] |
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| | Henrion, Daniel [VerfasserIn] |
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| | Offermanns, Stefan [VerfasserIn] |
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| Titel: | Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance |
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| Verf.angabe: | Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns |
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| E-Jahr: | 2019 |
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| Jahr: | 24 September 2019 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 14.02.2020 |
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| Titel Quelle: | Enthalten in: eLife |
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| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 8(2019) Artikel-Nummer e49374, 21 Seiten |
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| ISSN Quelle: | 2050-084X |
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| Abstract: | Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myogenic autoregulation are poorly understood. Here, we show that small arteries from mice with smooth muscle-specific loss of G12/G13 or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction. This defect was accompanied by loss of RhoA activation, while vessels showed normal increases in intracellular [Ca2+]. In the absence of myogenic vasoconstriction, perfusion of peripheral organs was increased, systemic vascular resistance was reduced and cardiac output and left ventricular mass were increased. In addition, animals with defective myogenic vasoconstriction showed aggravated hypotension in response to endotoxin. We conclude that G12/G13- and Rho-mediated signaling plays a key role in myogenic vasoconstriction and that myogenic tone is required to maintain local and systemic vascular resistance under physiological and pathological condition. |
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| DOI: | doi:10.7554/eLife.49374 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.49374 |
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| | DOI: https://doi.org/10.7554/eLife.49374 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | G-protein |
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| | myogenic tone |
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| | myogenic vasoconstriction |
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| | Rho/Rho-kinase |
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| | signal transduction |
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| | vascular smooth muscle |
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| K10plus-PPN: | 1690080019 |
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| Verknüpfungen: | → Zeitschrift |
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Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance / Chennupati, Ramesh [VerfasserIn]; 24 September 2019 (Online-Ressource)
