| |  Online-Ressource |
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| Verfasst von: | Rigalli, Juan Pablo [VerfasserIn]  |
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| | Dyckhoff, Gerhard [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Weiß, Johanna [VerfasserIn] |
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| Titel: | Human papilloma virus (HPV) 18 proteins E6 and E7 up-regulate ABC transporters in oropharyngeal carcinoma |
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| Titelzusatz: | involvement of the nonsense-mediated decay (NMD) pathway |
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| Verf.angabe: | Juan Pablo Rigalli, Matthias Reichel, Guillermo Nicolás Tocchetti, Tasmin Reuter, Gerhard Dyckhoff, Christel Herold-Mende, Johanna Weiss |
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| E-Jahr: | 2018 |
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| Jahr: | 30 April 2018 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 17.02.2020 |
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| Titel Quelle: | Enthalten in: Cancer letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 428(2018), Seite 69-76 |
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| ISSN Quelle: | 1872-7980 |
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| Abstract: | Oropharyngeal cancer incidence increased dramatically in the last decades, being infection with human papillomaviruses (HPV) a determinant of this trend. Concerning etiology, treatment response and prognosis, HPV+ and HPV− oropharyngeal cancers constitute different disease entities. The underlying molecular background is not completely understood. ATP-binding cassette (ABC) transporters mediate the efflux of anticancer drugs and are regulated by changes in the intracellular milieu. Furthermore, a role in cancer pathogenesis besides drug transport was reported. We evaluated the effect of transfection with E6 and E7 oncogenes from HPV16 and HPV18 on ABC transporters in oropharyngeal cancer cells. HPV18E6/E7 up-regulated P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and MRP2 expression in HNO206cells and breast cancer resistance protein (BCRP) in HNO206 and HNO413cells. While P-gp was regulated translationally, MRP1, MRP2 and BCRP up-regulation resulted from mRNA stabilization. For MRP1 and MRP2, the nonsense-mediated decay pathway was involved. In general, resistance to substrates of up-regulated transporters was increased. Transfection with oncogenes individually indicated a major role of HPV18E7. Our findings suggest ABC transporters as molecular players leading to differences in the pathogenesis of HPV+ and HPV− oropharyngeal cancer. |
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| DOI: | doi:10.1016/j.canlet.2018.04.036 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.canlet.2018.04.036 |
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| | Verlag: http://www.sciencedirect.com/science/article/pii/S0304383518303094 |
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| | DOI: https://doi.org/10.1016/j.canlet.2018.04.036 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ABC transporters |
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| | Head and neck squamous cell carcinoma |
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| | Human papillomavirus |
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| | Multidrug resistance |
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| | Nonsense mediated decay |
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| | Oropharyngeal cancer |
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| K10plus-PPN: | 1690126787 |
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| Verknüpfungen: | → Zeitschrift |
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Human papilloma virus (HPV) 18 proteins E6 and E7 up-regulate ABC transporters in oropharyngeal carcinoma / Rigalli, Juan Pablo [VerfasserIn]; 30 April 2018 (Online-Ressource)
