Imaging features of multiple myeloma extramedullary lesions in the liver with 18F-FDG PET/CT, contrast-enhanced CT and MRI

• Verfasst von: Papamichail, Dimitris [VerfasserIn]
• Verfasst von: Goldschmidt, Hartmut [VerfasserIn]
• Verfasst von: Dimitrakopoulou-Strauss, Antonia [VerfasserIn]
• Titel: Imaging features of multiple myeloma extramedullary lesions in the liver with 18F-FDG PET/CT, contrast-enhanced CT and MRI
• Verf.angabe: Dimitris Papamichail, Robert Hog, Hartmut Goldschmidt and Antonia Dimitrakopoulou-Strauss
• E-Jahr: 2019
• Jahr: 7 November 2019
• Umfang: 4 S.
• Fussnoten: Gesehen am 17.02.2020
• Titel Quelle: Enthalten in: Diagnostics
• Ort Quelle: Basel : MDPI, 2011
• Jahr Quelle: 2019
• Band/Heft Quelle: 9(2019,4) Artikel-Nummer 179, 4 Seiten
• ISSN Quelle: 2075-4418
• DOI: doi:10.3390/diagnostics9040179
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 18F-FDG PET/CT
• Sach-SW: contrast-enhanced CT
• Sach-SW: extramedullary
• Sach-SW: MRI
• Sach-SW: multiple myeloma
• K10plus-PPN: 1690127341

Abstract

Ηepatic involvement in multiple myeloma is not common; nevertheless, it is associated with poorer outcome. Heterogeneous features have been described in few published reports so far. We present the imaging findings of PET/CT in comparison to those of MRI for two multiple myeloma (MM) patients, one with a liver lesion suspicious for myeloma metastasis on PET and one with multiple liver lesions suspicious for myeloma metastases on MRΙ. The subsequent ultrasound-guided needle biopsies confirmed the extramedullary spread of the disease in both patients. The first case exhibited a match in both functional imaging modalities (PET and MRI) but a mismatch of intense metabolic activity on 18F-fluorodeoxyglucose (18F-FDG) PET/CT and iso-attenuating liver parenchyma on contrast-enhanced CT. The second case showed a mismatch of signal elevation persistence on diffusion-weighted imaging (DWI) and physiologic 18F-FDG distribution in the liver parenchyma. These cases present different imaging features in MM lesions of the liver using PET/CT and MRI, reflecting the high disease heterogeneity in patients with MM and demonstrating that the use of both PET/CT and MRI may offer complementary information.