| |  Online-Ressource |
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| Verfasst von: | Engel, Sinha [VerfasserIn]  |
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| | Klusmann, Hannah [VerfasserIn] |
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| | Laufer, Sebastian [VerfasserIn] |
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| | Pfeifer, Ann-Christin [VerfasserIn] |
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| | Ditzen, Beate [VerfasserIn] |
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| | van Zuiden, Mirjam [VerfasserIn] |
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| | Knaevelsrud, Christine [VerfasserIn] |
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| | Schumacher, Sarah [VerfasserIn] |
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| Titel: | Trauma exposure, posttraumatic stress disorder and oxytocin |
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| Titelzusatz: | a meta-analytic investigation of endogenous concentrations and receptor genotype |
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| Verf.angabe: | Sinha Engel, Hannah Klusmann, Sebastian Laufer, Ann-Christin Pfeifer, Beate Ditzen, Mirjam van Zuiden, Christine Knaevelsrud, Sarah Schumacher |
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| E-Jahr: | 2019 |
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| Jahr: | 11 August 2019 |
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| Umfang: | 42 S. |
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| Fussnoten: | Gesehen am 18.02.2020 |
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| Titel Quelle: | Enthalten in: Neuroscience & biobehavioral reviews |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1978 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 107(2019), Seite 560-601 |
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| ISSN Quelle: | 1873-7528 |
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| Abstract: | Oxytocin’s stress-reducing and social functions suggest an involvement in trauma processing and posttraumatic stress disorder (PTSD). We searched PubMed, PubPsych, PsycINFO, PsycARTICLES, Web of Science, ProQuest and ClinicalTrials.gov for studies assessing endogenous oxytocin, oxytocin receptor genotype or methylation in traumatized humans. Eligible studies (k=66) were systematically described. We meta-analytically compared oxytocin parameters between traumatized and non-traumatized individuals (k=17) and individuals with and without PTSD (k=8), and correlated oxytocin with trauma exposure (k=16) and PTSD symptoms (k=8). Endogenous oxytocin concentrations did not differ between PTSD patients and healthy individuals. The remaining effects on endogenous oxytocin were heterogeneous. Subgroup analyses identified sampling-related, trauma-related and demographic moderators, resulting in inconsistent or non-significant effects. Methylation data were insufficient for meta-analyses, and meta-analytic genotype results were inconsistent. Unstimulated endogenous oxytocin was not a biomarker for trauma exposure or PTSD. Given the impact of methodology, more basic research on endogenous oxytocin measurements is needed. Future studies might consider the oxytocin stress response and investigate oxytocin longitudinally. |
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| DOI: | doi:10.1016/j.neubiorev.2019.08.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neubiorev.2019.08.003 |
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| | Verlag: http://www.sciencedirect.com/science/article/pii/S0149763419300466 |
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| | DOI: https://doi.org/10.1016/j.neubiorev.2019.08.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Abuse |
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| | Adversity |
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| | Maltreatment |
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| | OXTR |
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| | Oxytocin receptor gene |
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| | Systematic review |
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| | Trauma |
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| | Traumatic experience |
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| K10plus-PPN: | 169022407X |
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| Verknüpfungen: | → Zeitschrift |
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Trauma exposure, posttraumatic stress disorder and oxytocin / Engel, Sinha [VerfasserIn]; 11 August 2019 (Online-Ressource)
