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Verfasst von:Schäfer, Jasmin [VerfasserIn]   i
 Pajonk, Oliver [VerfasserIn]   i
 Ruffini, Giulia [VerfasserIn]   i
 Papagiannidis, Dimitrios [VerfasserIn]   i
 Knop, Michael [VerfasserIn]   i
 Schuck, Sebastian [VerfasserIn]   i
Titel:ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast
Verf.angabe:Jasmin A. Schäfer, Julia P. Schessner, Peter W. Bircham, Takuma Tsuji, Charlotta Funaya, Oliver Pajonk, Katharina Schaeff, Giulia Ruffini, Dimitrios Papagiannidis, Michael Knop, Toyoshi Fujimoto & Sebastian Schuck
Jahr:2020
Umfang:20 S.
Fussnoten:5 December 2019 ; Gesehen am 18.02.2020
Titel Quelle:Enthalten in: European Molecular Biology OrganizationThe EMBO journal
Ort Quelle:Heidelberg : EMBO Press, 1982
Jahr Quelle:2020
Band/Heft Quelle:39(2020,2) Artikel-Nummer e102586, 20 Seiten
ISSN Quelle:1460-2075
Abstract:ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms. While dedicated machinery for macro-ER-phagy has been discovered, the molecules and mechanisms mediating micro-ER-phagy remain unknown. Here, we first show that micro-ER-phagy in yeast involves the conversion of stacked cisternal ER into multilamellar ER whorls during microautophagic uptake into lysosomes. Second, we identify the conserved Nem1-Spo7 phosphatase complex and the ESCRT machinery as key components for micro-ER-phagy. Third, we demonstrate that macro- and micro-ER-phagy are parallel pathways with distinct molecular requirements. Finally, we provide evidence that the ESCRT machinery directly functions in scission of the lysosomal membrane to complete the microautophagic uptake of ER. These findings establish a framework for a mechanistic understanding of micro-ER-phagy and, thus, a comprehensive appreciation of the role of autophagy in ER homeostasis.
DOI:doi:10.15252/embj.2019102586
URL:Volltext: https://doi.org/10.15252/embj.2019102586
 Verlag: https://www.embopress.org/doi/full/10.15252/embj.2019102586
 DOI: https://doi.org/10.15252/embj.2019102586
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:endoplasmic reticulum
 ESCRT machinery
 microautophagy
 yeast
K10plus-PPN:1690263954
Verknüpfungen:→ Zeitschrift
 
 
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