Cerebral sodium (23Na) magnetic resonance imaging in patients with migraine

• Verfasst von: Meyer, Melissa [VerfasserIn]
• Verfasst von: Schmidt, Alexander [VerfasserIn]
• Verfasst von: Benrath, Justus [VerfasserIn]
• Verfasst von: Konstandin, Simon [VerfasserIn]
• Verfasst von: Pilz, Lothar R. [VerfasserIn]
• Verfasst von: Harrington, Michael G. [VerfasserIn]
• Verfasst von: Budjan, Johannes [VerfasserIn]
• Verfasst von: Meyer, Mathias [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Haneder, Stefan [VerfasserIn]
• Titel: Cerebral sodium (23Na) magnetic resonance imaging in patients with migraine
• Titelzusatz: a case-control study
• Verf.angabe: Melissa M. Meyer, Alexander Schmidt, Justus Benrath, Simon Konstandin, Lothar R. Pilz, Michael G. Harrington, Johannes Budjan, Mathias Meyer, Lothar R. Schad, Stefan O. Schoenberg, Stefan Haneder
• E-Jahr: 2019
• Jahr: 01 July 2019
• Umfang: 8 S.
• Fussnoten: Gesehen am 19.02.2020
• Titel Quelle: Enthalten in: European radiology
• Ort Quelle: Berlin : Springer, 1991
• Jahr Quelle: 2019
• Band/Heft Quelle: 29(2019), 12, Seite 7055-7062
• ISSN Quelle: 1432-1084
• ISSN Quelle: 1613-3757
• DOI: doi:10.1007/s00330-019-06299-1
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1690347627

Abstract

Evaluation of MRI-derived cerebral 23Na concentrations in patients with migraine in comparison with healthy controls. Materials and methods. In this case-control study, 24 female migraine patients (mean age, 34 ± 11 years) were enrolled after evaluation of standardized questionnaires. Half (n = 12) of the cohort suffered from migraine, the other half was impaired by both migraine and tension-type headaches (TTH). The combined patient cohort was matched to 12 healthy female controls (mean age, 34 ± 11 years). All participants underwent a cerebral 23Na-magnetic resonance imaging examination at 3.0 T, which included a T1w MP-RAGE sequence and a 3D density-adapted, radial gradient echo sequence for 23Na imaging. Circular regions of interests were placed in predetermined anatomic regions: cerebrospinal fluid (CSF), gray and white matter, brain stem, and cerebellum. External 23Na reference phantoms were used to calculate the total 23Na tissue concentrations. Pearson’s correlation, Kendall Tau, and Wilcoxon rank sum test were used for statistical analysis. Results: 23Na concentrations of all patients in the CSF were significantly higher than in healthy controls (p < 0.001). The CSF of both the migraine and mixed migraine/TTH group showed significantly increased sodium concentrations compared to the control group (p = 0.007 and p < 0.001). Within the patient cohort, a positive correlation between pain level and TSC in the CSF (r = 0.62) could be observed. Conclusion: MRI-derived cerebral 23Na concentrations in the CSF of migraine patients were found to be statistically significantly higher than in healthy controls.