| |  Online-Ressource |
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| Verfasst von: | Pletsch-Borba, Laura [VerfasserIn]  |
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| | Turzanski Fortner, Renée [VerfasserIn] |
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| | Katzke, Verena [VerfasserIn] |
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| | Johnson, Theron S. [VerfasserIn] |
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| | Groß-Weissmann, Marie-Luise [VerfasserIn] |
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| | Hoffmeister, Michael [VerfasserIn] |
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| | Bugert, Peter [VerfasserIn] |
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| | Kaaks, Rudolf [VerfasserIn] |
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| | Kühn, Tilman [VerfasserIn] |
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| Titel: | Biomarkers of vascular injury and type 2 Diabetes |
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| Titelzusatz: | a prospective study, systematic review and meta-analysis |
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| Verf.angabe: | Laura Pletsch-Borba, Cora Watzinger, Renée Turzanski Fortner, Verena Katzke, Lukas Schwingshackl, Solomon A. Sowah, Anika Hüsing, Theron Johnson, Marie-Luise Groß, Sandra González Maldonado, Michael Hoffmeister, Peter Bugert, Rudolf Kaaks, Mirja Grafetstätter and Tilman Kühn |
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| E-Jahr: | 2019 |
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| Jahr: | 27 November 2019 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 19.02.2020 |
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| Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 8(2019,12) Artikel-Nummer 2075, 19 Seiten |
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| ISSN Quelle: | 2077-0383 |
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| Abstract: | Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC–Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC–Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding. |
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| DOI: | doi:10.3390/jcm8122075 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/jcm8122075 |
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| | Verlag: https://www.mdpi.com/2077-0383/8/12/2075 |
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| | DOI: https://doi.org/10.3390/jcm8122075 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | E-Selectin |
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| | Epidemiology |
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| | ICAM3 |
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| | P-Selectin |
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| | thrombomodulin |
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| | Type 2 Diabetes |
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| | vascular injury biomarkers |
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| K10plus-PPN: | 1690348747 |
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| Verknüpfungen: | → Zeitschrift |
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Biomarkers of vascular injury and type 2 Diabetes / Pletsch-Borba, Laura [VerfasserIn]; 27 November 2019 (Online-Ressource)
