Plasma sRAGE is independently associated with increased mortality in ARDS

• Verfasst von: Jabaudon, Matthieu [VerfasserIn]
• Verfasst von: Lichtenstern, Christoph [VerfasserIn]
• Verfasst von: Uhle, Florian [VerfasserIn]
• Titel: Plasma sRAGE is independently associated with increased mortality in ARDS
• Titelzusatz: a meta-analysis of individual patient data
• Verf.angabe: Matthieu Jabaudon, Raiko Blondonnet, Bruno Pereira, Rodrigo Cartin-Ceba, Christoph Lichtenstern, Tommaso Mauri, Rogier M. Determann, Tomas Drabek, Rolf D. Hubmayr, Ognjen Gajic, Florian Uhle, Andrea Coppadoro, Antonio Pesenti, Marcus J. Schultz, Marco V. Ranieri, Helena Brodska, Ségolène Mrozek, Vincent Sapin, Michael A. Matthay, Jean-Michel Constantin, Carolyn S. Calfee
• E-Jahr: 2018
• Jahr: 26 July 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 20.02.2020
• Titel Quelle: Enthalten in: Intensive care medicine
• Ort Quelle: Berlin : Springer, 1975
• Jahr Quelle: 2018
• Band/Heft Quelle: 44(2018), 9, Seite 1388-1399
• ISSN Quelle: 1432-1238
• DOI: doi:10.1007/s00134-018-5327-1
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1690458747

Abstract

The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients with ARDS and is associated with higher mortality, we hypothesized that baseline plasma sRAGE would predict mortality, independently of two key mediators of ventilator-induced lung injury.