Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Erb, Ulrike [VerfasserIn]  |
|---|
| | Schwerk, Christian [VerfasserIn] |
|---|
| | Schroten, Horst [VerfasserIn] |
|---|
| | Karremann, Michael [VerfasserIn] |
|---|
| Titel: | Review of functional in vitro models of the blood-cerebrospinal fluid barrier in leukaemia research |
|---|
| Verf.angabe: | Ulrike Erb, Christian Schwerk, Horst Schroten, Michael Karremann |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 1 January 2020 |
|---|
| Umfang: | 9 S. |
|---|
| Fussnoten: | Gesehen am 20.02.2020 ; Available online 24 October 2019 |
|---|
| Titel Quelle: | Enthalten in: Journal of neuroscience methods |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1979 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 329(2020) Artikel-Nummer 108478, 9 Seiten |
|---|
| ISSN Quelle: | 1872-678X |
|---|
| Abstract: | Acute lymphoblastic leukaemia represents the most common paediatric malignancy. Although survival rates approach up to 90% in children, investigation of leukaemic infiltration into the central nervous system (CNS) is essential due to the presence of ongoing fatal complications. Recent in vitro studies mostly employed models of the blood-brain barrier (BBB), as endothelial cells of the microvasculature represent the largest surface between the blood stream and the brain parenchyma. However, crossing the blood-cerebrospinal fluid barrier (BCSFB) within the choroid plexus (CP) has been shown to be a general capability of leukaemic blasts. Hence, in vitro models of the BCSFB to study leukaemic transmigration may be of major importance to understand the development of CNS leukaemia. This review will summarise available in vitro models of the BCSFB employed to study the cellular interactions with leukaemic blasts during cancer cell transmigration into the brain compartment across primary or immortal/immortalised BCSFB cells. It will also provide an outlook on prospective improvements in BCSFB in vitro models by developing barrier-on-a-chip models and brain organoids. |
|---|
| DOI: | doi:10.1016/j.jneumeth.2019.108478 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jneumeth.2019.108478 |
|---|
| | Verlag: http://www.sciencedirect.com/science/article/pii/S0165027019303358 |
|---|
| | DOI: https://doi.org/10.1016/j.jneumeth.2019.108478 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Acute lymphoblastic leukaemia |
|---|
| | Blood-cerebrospinal fluid barrier |
|---|
| | Choroid plexus |
|---|
| | CNS invasion |
|---|
| | Transmigration |
|---|
| K10plus-PPN: | 1690464666 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Review of functional in vitro models of the blood-cerebrospinal fluid barrier in leukaemia research / Erb, Ulrike [VerfasserIn]; 1 January 2020 (Online-Ressource)
68491613
