In vivo laser confocal microscopy using the HRT-Rostock cornea module

• Verfasst von: Lim, Lyndell L. [VerfasserIn]
• Verfasst von: Becker, Matthias D. [VerfasserIn]
• Verfasst von: Mackensen, Friederike [VerfasserIn]
• Titel: In vivo laser confocal microscopy using the HRT-Rostock cornea module
• Titelzusatz: Diversity and Diagnostic Implications in Patients with Uveitis
• Verf.angabe: Lyndell L. Lim, Jing Xie, Chyn C. Chua, Tiffany Wong, Lani T. Hoang, Matthias D. Becker, Eric B. Suhler, James T. Rosenbaum, Friederike Mackensen
• E-Jahr: 2018
• Jahr: [2018]
• Jahr des Originals: 2017
• Umfang: 10 S.
• Fussnoten: Published online: 31 May 2017 ; Gesehen am 20.02.2020
• Titel Quelle: Enthalten in: Ocular immunology and inflammation
• Ort Quelle: Abingdon : Taylor & Francis Group, 1993
• Jahr Quelle: 2018
• Band/Heft Quelle: 26(2018), 6, Seite 900-909
• ISSN Quelle: 1744-5078
• DOI: doi:10.1080/09273948.2017.1298818
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Confocal microscopy
• Sach-SW: imaging analysis
• Sach-SW: keratic precipitates
• Sach-SW: uveitis
• K10plus-PPN: 1690548517

Abstract

Purpose: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications.Methods: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers.Results: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with active infectious uveitis (p < 0.01): patients with cluster KP (odds ratio [OR] = 3.03, 95% confidence interval [CI]: 1.43, 6.45) and nodular KP (OR = 3.89, 95% CI: 1.42, 10.65) were more likely to have infectious uveitis than those without.Conclusions: Laser confocal microscopy of KP may have a role in determining between infectious and non-infectious uveitis.