Frame-based stereotactic biopsies using an intraoperative MR-scanner are as safe and effective as conventional stereotactic procedures

• Verfasst von: Neumann, Jan-Oliver [VerfasserIn]
• Verfasst von: Campos, Benito [VerfasserIn]
• Verfasst von: Younes, Bilal [VerfasserIn]
• Verfasst von: Jakobs, Martin [VerfasserIn]
• Verfasst von: Jungk, Christine [VerfasserIn]
• Verfasst von: Beynon, Christopher [VerfasserIn]
• Verfasst von: Deimling, Andreas von [VerfasserIn]
• Verfasst von: Unterberg, Andreas [VerfasserIn]
• Verfasst von: Kiening, Karl [VerfasserIn]
• Titel: Frame-based stereotactic biopsies using an intraoperative MR-scanner are as safe and effective as conventional stereotactic procedures
• Verf.angabe: Jan-Oliver Neumann, Benito Campos, Bilal Younes, Martin Jakobs, Christine Jungk, Christopher Beynon, Andreas von Deimling, Andreas Unterberg, Karl Kiening
• E-Jahr: 2018
• Jahr: October 23, 2018
• Umfang: 14 S.
• Fussnoten: Gesehen am 21.02.2020
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2018
• Band/Heft Quelle: 13(2018,10) Artikel-Nr. e0205772, 14 Seiten
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0205772
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biopsy
• Sach-SW: Computed axial tomography
• Sach-SW: General anesthesia
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Metaanalysis
• Sach-SW: Neuroimaging
• Sach-SW: Surgeons
• Sach-SW: Surgical and invasive medical procedures
• K10plus-PPN: 1690663200

Abstract

Background: Frame-based stereotactic biopsy (FBSB) is a minimally-invasive and effective procedure for the diagnosis of brain lesions and will likely gain clinical importance. Since FBSB procedures comprise a variety of imaging and sampling methods, it is necessary to compare the safety and effectiveness of individual techniques. Objective: To assess the safety and effectiveness of FBSB using 1.5T iMRI as a one-stop procedure under general anesthesia without intraoperative histological examination. Methods: In this single-center, retrospective analysis, 500 consecutive FBSBs using iMRI were compared to a historic control of 100 biopsies with traditional workflows (computed tomography (CT) with MRI image fusion). All procedures were performed under general anesthesia. Data on surgical procedures, pre- and postoperative neurologic patient status, complications and diagnostic yield were extracted from clinical records. Results: Complication rates and diagnostic yield showed no significant differences between both groups. Mortality was 0.6%, 95% CI = [0.12%, 1.74%], in the iMRI and 0.0% [0.00%, 3.62%], in the control group with a morbidity of 5.4% [3.6%, 7.8%] and 6.0% [2.2%, 12.6%] and a diagnostic yield of 96.8% [94.9%, 98.2%] and 96.0% [90.1%, 98.9%]. Mean procedure duration was 124 [121, 127] minutes using iMRI and 112 [106, 118] minutes in the control group. Conclusion: FBSB using 1.5T iMRI under general anesthesia is a safe and effective procedure and is equivalent to traditional stereotactic workflows with respect to complication rate and diagnostic yield.