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Status: Bibliographieeintrag

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Verfasst von:Schupp, Tobias [VerfasserIn]   i
 Behnes, Michael [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Lang, Siegfried [VerfasserIn]   i
 Akın, Ibrahim [VerfasserIn]   i
 Reiser, Linda [VerfasserIn]   i
 Kern-Bollow, Armin [VerfasserIn]   i
 Taton, Gabriel [VerfasserIn]   i
 Reichelt, Thomas [VerfasserIn]   i
 Ellguth, Dominik [VerfasserIn]   i
 Engelke, Niko [VerfasserIn]   i
 Borggrefe, Martin [VerfasserIn]   i
Titel:Prognostic impact of angiotensin-converting enzyme inhibitors and receptor blockers on recurrent ventricular tachyarrhythmias and implantable cardioverter-defibrillator therapies
Verf.angabe:Tobias Schupp, Michael Behnes, Christel Weiß, Christoph Nienaber, Siegfried Lang, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Thomas Bertsch, Muharrem Akin, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin
E-Jahr:2019
Jahr:May 2019
Umfang:10 S.
Fussnoten:Gesehen am 24.02.2020
Titel Quelle:Enthalten in: Journal of cardiovascular pharmacology
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1979
Jahr Quelle:2019
Band/Heft Quelle:73(2019), 5, Seite 272-281
ISSN Quelle:1533-4023
Abstract:Abstract: This study sought to assess the prognostic impact of treatment with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) on recurrences of ventricular tachyarrhythmias in recipients of implantable cardioverter-defibrillators (ICD). Using a large retrospective registry including consecutive ICD recipients with documented episodes of ventricular tachycardia (VT) or fibrillation (VF) from 2002 to 2016, those patients treated with ACEi/ARB were compared with patients without. The primary prognostic endpoint was the first recurrence of ventricular tachyarrhythmias and related ICD therapies at 5 years. Multivariable Cox regression analyses were applied within the entire cohort, and thereafter, Kaplan-Meier analyses were performed in propensity-matched subgroups. A total of 592 consecutive ICD recipients were included (81% treated with ACEi/ARB and 19% without). Although ACEi/ARB was associated with no differences in overall recurrence of ventricular tachyarrhythmias, ACEi/ARB was associated with improved freedom from appropriate ICD therapy within multivariable Cox regressions (hazard ratio = 0.666; P = 0.043), especially in patients with index episodes of VF, left ventricular ejection fraction <35%, coronary artery disease, secondary preventive ICD, and glomerular filtration rate <45 mL/min/1.73 m2. In the propensity-matched subgroup, ACEi/ARB still prolonged freedom from appropriate ICD therapies (hazard ratio = 0.380; 95% confidence interval 0.193-0.747; P = 0.005). In conclusion, ACEi/ARB therapy was associated with improved freedom from appropriate ICD therapies.
DOI:doi:10.1097/FJC.0000000000000659
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/FJC.0000000000000659
 Volltext: https://journals.lww.com/cardiovascularpharm/Abstract/2019/05000/Prognostic_Impact_of_Angiotensin_Converting_Enzyme.2.as ...
 DOI: https://doi.org/10.1097/FJC.0000000000000659
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1690851201
Verknüpfungen:→ Zeitschrift

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