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Status: Bibliographieeintrag

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Verfasst von:Nees, Timo A. [VerfasserIn]   i
 Tappe-Theodor, Anke [VerfasserIn]   i
 Sliwinski, Christopher [VerfasserIn]   i
 Motsch, Melanie [VerfasserIn]   i
 Rupp, Rüdiger [VerfasserIn]   i
 Kuner, Rohini [VerfasserIn]   i
 Weidner, Norbert [VerfasserIn]   i
 Blesch, Armin [VerfasserIn]   i
Titel:Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury
Verf.angabe:Timo A. Nees, Anke Tappe-Theodor, Christopher Sliwinski, Melanie Motsch, Rüdiger Rupp, Rohini Kuner, Norbert Weidner, Armin Blesch
Jahr:2016
Umfang:11 S.
Fussnoten:Available online 14 November 2015 ; Gesehen am 24.02.2020
Titel Quelle:Enthalten in: Pain
Ort Quelle:New York, NY [u.a.] : Lippincott Williams and Wilkins, 1975
Jahr Quelle:2016
Band/Heft Quelle:157(2016), 3, Seite 687-697
ISSN Quelle:1872-6623
Abstract:Below-level central neuropathic pain (CNP) affects a large proportion of spinal cord injured individuals. To better define the dynamic changes of the spinal cord neural network contributing to the development of CNP after spinal cord injury (SCI), we characterized the morphological and behavioral correlates of CNP in female C57BL/6 mice after a moderate T11 contusion SCI (50 kdyn) and the influence of moderate physical activity. Compared with sham-operated animals, injured mice developed mechanical allodynia 2 weeks post injury when tested with small-diameter von Frey hair filaments (0.16 g and 0.4 g filament), but presented hyporesponsiveness to noxious mechanical stimuli (1.4 g filament). The mechano-sensory alterations lasted up to 35 days post injury, the longest time point examined. The response latency to heat stimuli already decreased significantly 10 days post injury reaching a plateau 2 weeks later. In contrast, injured mice developed remarkable hyposensitivity to cold stimuli. Animals that underwent moderate treadmill training (2 × 15 minutes; 5 d/wk) showed a significant reduction in the response rate to light mechanical stimuli as early as 6 days after training. Calcitonin gene-related peptide (CGRP) labeling in lamina III-IV of the dorsal horn revealed significant increases in CGRP-labeling density in injured animals compared with sham control animals. Importantly, treadmill training reduced CGRP-labeling density by about 50% (P < 0.01), partially reducing the injury-induced increases. Analysis of IB4-labeled nonpeptidergic sensory fibers revealed no differences between experimental groups. Abnormalities in temperature sensation were not influenced by physical activity. Thus, treadmill training partially resolves signs of below-level CNP after SCI and modulates the density of CGRP-labeled fibers.
DOI:doi:10.1097/j.pain.0000000000000422
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/j.pain.0000000000000422
 Volltext: https://journals.lww.com/pain/Fulltext/2016/03000/Early_onset_treadmill_training_reduces_mechanical.20.aspx
 DOI: https://doi.org/10.1097/j.pain.0000000000000422
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1690868414
Verknüpfungen:→ Zeitschrift

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