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Verfasst von:Papageorgiou, Ismini E. [VerfasserIn]   i
 Valous, Nektarios A. [VerfasserIn]   i
 Lahrmann, Bernd [VerfasserIn]   i
 Grabe, Niels [VerfasserIn]   i
 Halama, Niels [VerfasserIn]   i
 Kann, Oliver [VerfasserIn]   i
Titel:Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus
Verf.angabe:Ismini E. Papageorgiou, Nektarios A. Valous, Bernd Lahrmann, Hana Janova, Zin-Juan Klaft, Arend Koch, Ulf C. Schneider, Peter Vajkoczy, Frank L. Heppner, Niels Grabe, Niels Halama, Uwe Heinemann, Oliver Kann
E-Jahr:2018
Jahr:19 January 2018
Umfang:14 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 24.02.2020
Titel Quelle:Enthalten in: Glia
Ort Quelle:Bognor Regis [u.a.] : Wiley-Liss, 1988
Jahr Quelle:2018
Band/Heft Quelle:66(2018), 5, Seite 920-933
ISSN Quelle:1098-1136
Abstract:Human mesial temporal lobe epilepsy (MTLE) features subregion-specific hippocampal neurodegeneration and reactive astrogliosis, including up-regulation of the glial fibrillary acidic protein (GFAP) and down-regulation of glutamine synthetase (GS). However, the regional astrocytic expression pattern of GFAP and GS upon MTLE-associated neurodegeneration still remains elusive. We assessed GFAP and GS expression in strict correlation with the local neuronal number in cortical and hippocampal surgical specimens from 16 MTLE patients using immunohistochemistry, stereology and high-resolution image analysis for digital pathology and whole-slide imaging. In the cortex, GS-positive (GS+) astrocytes are dominant in all neuronal layers, with a neuron to GS+ cell ratio of 2:1. GFAP-positive (GFAP+) cells are widely spaced, with a GS+ to GFAP+ cell ratio of 3:1-5:1. White matter astrocytes, on the contrary, express mainly GFAP and, to a lesser extent, GS. In the hippocampus, the neuron to GS+ cell ratio is approximately 1:1. Hippocampal degeneration is associated with a reduction of GS+ astrocytes, which is proportional to the degree of neuronal loss and primarily present in the hilus. Up-regulation of GFAP as a classical hallmark of reactive astrogliosis does not follow the GS-pattern and is prominent in the CA1. Reactive alterations were proportional to the neuronal loss in the neuronal somatic layers (stratum pyramidale and hilus), while observed to a lesser extent in the axonal/dendritic layers (stratum radiatum, molecular layer). We conclude that astrocytic GS is expressed in the neuronal somatic layers and, upon neurodegeneration, is down-regulated proportionally to the degree of neuronal loss.
DOI:doi:10.1002/glia.23292
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/glia.23292
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.23292
 DOI: https://doi.org/10.1002/glia.23292
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:astroglia
 digital pathology
 GFAP
 hippocampal sclerosis
 stereology
K10plus-PPN:1690879009
Verknüpfungen:→ Zeitschrift

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