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Verfasst von:Larribere, Lionel [VerfasserIn]   i
 Sachpekidis, Christos [VerfasserIn]   i
 Hüser, Laura [VerfasserIn]   i
 Utikal, Jochen [VerfasserIn]   i
Titel:Targeted therapy-resistant melanoma cells acquire transcriptomic similarities with human melanoblasts
Verf.angabe:Lionel Larribère, Silke Kuphal, Christos Sachpekidis, Sachindra, Laura Hüser, Anja Bosserhoff and Jochen Utikal
E-Jahr:2018
Jahr:16 November 2018
Umfang:12 S.
Fussnoten:Gesehen am 25.02.2020
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2018
Band/Heft Quelle:10(2018, 11) Artikel-Nummer 451, 12 Seiten
ISSN Quelle:2072-6694
Abstract:The mechanisms of adaptive and acquired drug resistance in tumors are not completely understood. So far, gene amplifications or mutations, leading to the reactivation of the MAPK or PI3K pathways have been described. In this study, we used two different methods to generate human melanoblasts: (1) via differentiation from induced pluripotent stem cells (iPSCs) and (2) via dedifferentiation from melanocytes. The melanoblast transcriptomes were then compared to the transcriptome of MAPK inhibitor-resistant melanoma cells. We observed that the expression of genes associated with cell cycle control, DNA damage control, metabolism, and cancer was altered in both melanoblast populations and in both adaptive and acquired resistant melanoma samples, compared to drug-sensitive samples. However, genes involved in antigen presentation and cellular movement were only regulated in the melanoblast populations and in the acquired resistant melanoma samples, compared to the drug-sensitive samples. Moreover, melanocyte-derived melanoblasts and adaptive resistant melanoma samples were characterized by different expression levels of certain transcription factors or genes involved in the CDK5 pathway. In conclusion, we show here that in vitro models of human melanoblasts are very important tools to comprehend the expression profiles of drug-resistant melanoma.
DOI:doi:10.3390/cancers10110451
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/cancers10110451
 Verlag: https://www.mdpi.com/2072-6694/10/11/451
 DOI: https://doi.org/10.3390/cancers10110451
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:differentiation
 iPSCs
 melanoblast
 melanoma
 resistance
K10plus-PPN:1690893737
Verknüpfungen:→ Zeitschrift

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