Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Rupp, Christian [VerfasserIn]   i
 Bode, Konrad A. [VerfasserIn]   i
 Weiss, Karl Heinz [VerfasserIn]   i
 Rudolph, Gerda [VerfasserIn]   i
 Bergemann, Janine [VerfasserIn]   i
 Klöters-Plachky, Petra [VerfasserIn]   i
 Chahoud, Fadi [VerfasserIn]   i
 Stremmel, Wolfgang [VerfasserIn]   i
 Gotthardt, Daniel [VerfasserIn]   i
 Sauer, Peter [VerfasserIn]   i
Titel:Microbiological assessment of bile and corresponding antibiotic treatment
Titelzusatz:a strobe-compliant observational study of 1401 endoscopic retrograde cholangiographies
Verf.angabe:Christian Rupp, MD, Konrad Bode, MD, Karl Heinz Weiss, MD, Gerda Rudolph, Janine Bergemann, Petra Kloeters-Plachky, Fadi Chahoud, MD, Wolfgang Stremmel, MD, PhD, Daniel Nils Gotthardt, MD, and Peter Sauer, MD
E-Jahr:2016
Jahr:March 2016
Fussnoten:accepted: December 4, 2015 ; Gesehen am 27.02.2020
Titel Quelle:Enthalten in: Medicine
Ort Quelle:Baltimore, Md. : Lippincott Williams & Wilkins, 1922
Jahr Quelle:2016
Band/Heft Quelle:95(2016,10) Artikel-Nummer e2390, 8 Seiten
ISSN Quelle:1536-5964
Abstract:The aim of this study was to determine the antibiotic susceptibility profiles of bacteria in bile samples and to analyze the clinical relevance of the findings as only limited information about risk factors for elevated frequence of bacterial and fungal strains in routinely collected bile samples has been described so far. - A prospective cohort study at a tertiary care center was conducted. Seven hundred forty-four patients underwent 1401 endoscopic retrograde cholangiographies (ERCs) as indicated by liver transplantation (427/1401), primary sclerosing cholangitis (222/1401), choledocholithiasis only (153/1401), obstruction due to malignancy (366/1401), or other conditions (233/1401). Bile samples for microbiological analysis were obtained in all patients. - The 71.6% (823/1150) samples had a positive microbiological finding, and 57% (840/1491) of the bacterial isolates were gram-positive. The main species were Enterococcus spp (33%; 494/1491) and Escherichia coli (12%; 179/1491). Of the samples, 53.8% had enteric bacteria and 24.7% had Candida spp; both were associated with clinical and laboratory signs of cholangitis (C-reactive proteins 35.0 ± 50.1 vs 44.8 ± 57.6; 34.5 ± 51.2 vs 52.9 ± 59.7; P < 0.001), age, previous endoscopic intervention, and immunosuppression. Multi-resistant (MR) strains were found in 11.3% of all samples and were associated with clinical and laboratory signs of cholangitis, previous intervention, and immunocompromised status. In subgroup analysis, strain-specific antibiotic therapy based on bile sampling was achieved in 56.3% (89/158) of the patients. In cases with a positive bile culture and available blood culture, blood cultures were positive in 29% of cases (36/124), and 94% (34/36) of blood cultures had microbial species identical to the bile cultures. - Bactobilia and fungobilia can usually be detected by routine microbiological sampling, allowing optimized, strain-specific antibiotic treatment. Previous endoscopic intervention, clinical and laboratory signs of cholangitis, and age are independent risk factors. MR bacteria and fungi are an evolving problem in cholangitis, especially in immunocompromised patients.
DOI:doi:10.1097/MD.0000000000002390
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1097/MD.0000000000002390
 Volltext: https://journals.lww.com/md-journal/fulltext/2016/03080/Microbiological_Assessment_of_Bile_and.5.aspx
 DOI: https://doi.org/10.1097/MD.0000000000002390
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1691145203
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68494065   QR-Code
zum Seitenanfang