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Verfasst von:Fritze, Stefan [VerfasserIn]   i
 Kubera, Katharina Maria [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
 Hirjak, Dusan [VerfasserIn]   i
Titel:Neurological soft signs in schizophrenia spectrum disorders are not confounded by current antipsychotic dosage
Verf.angabe:Stefan Fritze, Fabio Sambataro, Katharina M. Kubera, Alina L. Bertolino, Cristina E. Topor, Robert C. Wolf, Dusan Hirjak
Jahr:2020
Jahr des Originals:2019
Umfang:11 S.
Fussnoten:Available online 25 November 2019 ; Gesehen am 27.02.2020
Titel Quelle:Enthalten in: European neuropsychopharmacology
Ort Quelle:Amsterdam : Elsevier, 1990
Jahr Quelle:2020
Band/Heft Quelle:31(2020), Seite 47-57
ISSN Quelle:1873-7862
Abstract:Neurological soft signs (NSS) have garnered increasing attention in psychiatric research on motor abnormalities in schizophrenia spectrum disorders (SSD). However, it remains unclear whether the assessment of NSS severity could have been confounded by current antipsychotic dosage. In this study, we recruited 105 patients with SSD that underwent a comprehensive motor assessment evaluating NSS and extrapyramidal motor symptoms (EPMS) by means of standardized instruments. Current antipsychotic dosage equivalence estimates were determined by the classical mean dose method (doses equivalent to 1 mg/d olanzapine). We used multiple regression analyses to describe the relationship between NSS, EPMS and antipsychotic medication. In line with our expectations, current antipsychotic dosage had no significant effects on NSS total score (p = 0.27), abnormal involuntary movements (p = 0.17), akathisia (p = 0.32) and parkinsonism (p = 0.26). Further, NSS total score had a significant effect on akathisia (p = 0.003) and parkinsonism (p = 0.0001, Bonferroni corr.), but only marginal effect on abnormal involuntary movements (p = 0.08). Our results support the notion that NSS are not significantly modulated by current antipsychotic dosage in SSD. The associations between NSS, akathisia and parkinsonism, as revealed by this study, support the genuine rather than medication-dependent origin of particular motor abnormalities in SSD.
DOI:doi:10.1016/j.euroneuro.2019.11.001
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.euroneuro.2019.11.001
 Verlag: http://www.sciencedirect.com/science/article/pii/S0924977X19317274
 DOI: https://doi.org/10.1016/j.euroneuro.2019.11.001
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Akathisia
 Antipsychotics
 EPMS
 Neurological softs signs
 Parkinsonism
 Schizophrenia spectrum disorders
K10plus-PPN:1691177768
Verknüpfungen:→ Zeitschrift

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