| Online-Ressource |
Verfasst von: | Bauer, Tobias Hartmut [VerfasserIn]  |
| Mallm, Jan-Philipp [VerfasserIn]  |
| Geörg, Christina [VerfasserIn]  |
| Rippe, Karsten [VerfasserIn]  |
| Herrmann, Carl [VerfasserIn]  |
| Eils, Roland [VerfasserIn]  |
Titel: | Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children |
Verf.angabe: | Tobias Bauer, Saskia Trump, Naveed Ishaque, Loreen Thürmann, Lei Gu, Mario Bauer, Matthias Bieg, Zuguang Gu, Dieter Weichenhan, Jan-Philipp Mallm, Stefan Röder, Gunda Herberth, Eiko Takada, Oliver Mücke, Marcus Winter, Kristin M Junge, Konrad Grützmann, Ulrike Rolle-Kampczyk, Qi Wang, Christian Lawerenz, Michael Borte, Tobias Polte, Matthias Schlesner, Michaela Schanne, Stefan Wiemann, Christina Geörg, Hendrik G Stunnenberg, Christoph Plass, Karsten Rippe, Junichiro Mizuguchi, Carl Herrmann, Roland Eils & Irina Lehmann |
E-Jahr: | 2016 |
Jahr: | 24 March 2016 |
Fussnoten: | Gesehen am 27.02.2020 |
Titel Quelle: | Enthalten in: Molecular systems biology |
Ort Quelle: | Heidelberg : EMBO Press, 2005 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 12(2016,3) Artikel-Nummer 861, 18 Seiten |
ISSN Quelle: | 1744-4292 |
Abstract: | Abstract Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype-related DNA methylation changes. Differential methylation is enriched in enhancer elements and targets in particular ?commuting? enhancers having multiple, regulatory interactions with distal genes. Longitudinal whole-genome bisulfite sequencing revealed that DNA methylation changes associated with maternal smoking persist over years of life. Particularly in children prenatal environmental exposure leads to chromatin transitions into a hyperactive state. Combined DNA methylation, histone modification, and gene expression analyses indicate that differential methylation in enhancer regions is more often functionally translated than methylation changes in promoters or non-regulatory elements. Finally, we show that epigenetic deregulation of a commuting enhancer targeting c-Jun N-terminal kinase 2 (JNK2) is linked to impaired lung function in early childhood. |
DOI: | doi:10.15252/msb.20156520 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.15252/msb.20156520 |
| Volltext: https://www.embopress.org/doi/full/10.15252/msb.20156520 |
| DOI: https://doi.org/10.15252/msb.20156520 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | enhancer deregulation |
| environment |
| epigenetics |
| histone modifications |
| WGBS |
K10plus-PPN: | 1691179361 |
Verknüpfungen: | → Zeitschrift |
Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children / Bauer, Tobias Hartmut [VerfasserIn]; 24 March 2016 (Online-Ressource)