Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Bauer, Tobias Hartmut [VerfasserIn]   i
 Mallm, Jan-Philipp [VerfasserIn]   i
 Geörg, Christina [VerfasserIn]   i
 Rippe, Karsten [VerfasserIn]   i
 Herrmann, Carl [VerfasserIn]   i
 Eils, Roland [VerfasserIn]   i
Titel:Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children
Verf.angabe:Tobias Bauer, Saskia Trump, Naveed Ishaque, Loreen Thürmann, Lei Gu, Mario Bauer, Matthias Bieg, Zuguang Gu, Dieter Weichenhan, Jan-Philipp Mallm, Stefan Röder, Gunda Herberth, Eiko Takada, Oliver Mücke, Marcus Winter, Kristin M Junge, Konrad Grützmann, Ulrike Rolle-Kampczyk, Qi Wang, Christian Lawerenz, Michael Borte, Tobias Polte, Matthias Schlesner, Michaela Schanne, Stefan Wiemann, Christina Geörg, Hendrik G Stunnenberg, Christoph Plass, Karsten Rippe, Junichiro Mizuguchi, Carl Herrmann, Roland Eils & Irina Lehmann
E-Jahr:2016
Jahr:24 March 2016
Fussnoten:Gesehen am 27.02.2020
Titel Quelle:Enthalten in: Molecular systems biology
Ort Quelle:Heidelberg : EMBO Press, 2005
Jahr Quelle:2016
Band/Heft Quelle:12(2016,3) Artikel-Nummer 861, 18 Seiten
ISSN Quelle:1744-4292
Abstract:Abstract Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype-related DNA methylation changes. Differential methylation is enriched in enhancer elements and targets in particular ?commuting? enhancers having multiple, regulatory interactions with distal genes. Longitudinal whole-genome bisulfite sequencing revealed that DNA methylation changes associated with maternal smoking persist over years of life. Particularly in children prenatal environmental exposure leads to chromatin transitions into a hyperactive state. Combined DNA methylation, histone modification, and gene expression analyses indicate that differential methylation in enhancer regions is more often functionally translated than methylation changes in promoters or non-regulatory elements. Finally, we show that epigenetic deregulation of a commuting enhancer targeting c-Jun N-terminal kinase 2 (JNK2) is linked to impaired lung function in early childhood.
DOI:doi:10.15252/msb.20156520
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.15252/msb.20156520
 Volltext: https://www.embopress.org/doi/full/10.15252/msb.20156520
 DOI: https://doi.org/10.15252/msb.20156520
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:enhancer deregulation
 environment
 epigenetics
 histone modifications
 WGBS
K10plus-PPN:1691179361
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68494162   QR-Code
zum Seitenanfang