Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke

• Verfasst von: Palm, Frederick [VerfasserIn]
• Verfasst von: Pussinen, Pirkko J. [VerfasserIn]
• Verfasst von: Safer, Anton [VerfasserIn]
• Verfasst von: Tervahartiala, Taina [VerfasserIn]
• Verfasst von: Sorsa, Timo [VerfasserIn]
• Verfasst von: Urbanek, Christian [VerfasserIn]
• Verfasst von: Becher, Heiko [VerfasserIn]
• Verfasst von: Grau, Armin J. [VerfasserIn]
• Titel: Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke
• Verf.angabe: Frederick Palm, Pirkko J. Pussinen, Anton Safer, Taina Tervahartiala, Timo Sorsa, Christian Urbanek, Heiko Becher, Armin J. Grau
• E-Jahr: 2018
• Jahr: 8 February 2018
• Umfang: 6 S.
• Illustrationen: Diagramme
• Fussnoten: Gesehen am 27.02.2020
• Titel Quelle: Enthalten in: Atherosclerosis
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1970
• Jahr Quelle: 2018
• Band/Heft Quelle: 271(2018), Seite 9-14
• ISSN Quelle: 1879-1484
• DOI: doi:10.1016/j.atherosclerosis.2018.02.012
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Inflammation
• Sach-SW: Ischemic stroke
• Sach-SW: MMP-8
• Sach-SW: MPO
• K10plus-PPN: 1691199249

Abstract

Background and aims - Matrix metalloproteinase (MMP)-8 and myeloperoxidase (MPO) may contribute to cerebral damage in acute ischemic stroke. We tested the hypothesis that levels of MPO, MMP-8 and the ratio between MMP-8 and its regulator, tissue inhibitor of metalloproteinase (TIMP-1), are increased in acute ischemic stroke and its etiologic subgroups and they correlate with stroke severity. - Methods - In a cross-sectional case-control study, serum concentrations of MMP-8, MPO and TIMP-1 were assessed within 24h after admission in 470 first-ever ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population. Odds ratios (OR) per decade of log transformed dependent variables were calculated and adjusted for age, sex and vascular risk factors. - Results - Levels of MMP-8 (OR 4.9; 95% CI 3.4-7.2), MMP-8/TIMP-1 ratio (3.0; 2.2-4.1) and MPO (6.6; 4.0-11.0) were independently associated with ischemic stroke. MMP-8 levels differed between etiologic stroke subgroups (p=0.019, ANOVA), with higher levels in cardioembolic stroke and stroke due to large vessel disease, and lower levels in microangiopathic stroke. MMP-8, MMP-8/TIMP-1 ratio and MPO (p < 0.001) concentrations showed positive associations with stroke severity independent of stroke etiology. - Conclusions - Concentrations of serum neutrophil markers are increased after ischemic stroke and associate with stroke severity and etiology. The value of these biomarkers in diagnostics and prognostics is worth being evaluated.