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Verfasst von:Thielmann, Carl Maximilian [VerfasserIn]   i
 Costa da Silva, Milene [VerfasserIn]   i
 Muley, Thomas [VerfasserIn]   i
 Meister, Michael [VerfasserIn]   i
 Herpel, Esther [VerfasserIn]   i
 Muckenthaler, Martina [VerfasserIn]   i
Titel:Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
Verf.angabe:Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler
E-Jahr:2019
Jahr:05 August 2019
Fussnoten:Gesehen am 28.02.2020
Titel Quelle:Enthalten in: Scientific reports
Ort Quelle:[London] : Macmillan Publishers Limited, part of Springer Nature, 2011
Jahr Quelle:2019
Band/Heft Quelle:9(2019) Artikel-Nummer 11326, 9 Seiten
ISSN Quelle:2045-2322
Abstract:Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy.
DOI:doi:10.1038/s41598-019-47833-x
URL:Kostenfrei: Volltext ; Verlag: https://doi.org/10.1038/s41598-019-47833-x
 Kostenfrei: Volltext: https://www.nature.com/articles/s41598-019-47833-x
 DOI: https://doi.org/10.1038/s41598-019-47833-x
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1691243787
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