| Online-Ressource |
Verfasst von: | Warth, Arne [VerfasserIn]  |
| Körner, Sandrina [VerfasserIn]  |
| Penzel, Roland [VerfasserIn]  |
| Muley, Thomas [VerfasserIn]  |
| Dienemann, Hendrik [VerfasserIn]  |
| Schirmacher, Peter [VerfasserIn]  |
| Knebel Doeberitz, Magnus von [VerfasserIn]  |
| Weichert, Wilko [VerfasserIn]  |
| Kloor, Matthias [VerfasserIn]  |
Titel: | Microsatellite instability in pulmonary adenocarcinomas |
Titelzusatz: | a comprehensive study of 480 cases |
Verf.angabe: | Arne Warth, Sandrina Körner, Roland Penzel, Thomas Muley, Hendrik Dienemann, Peter Schirmacher, Magnus von Knebel-Doeberitz, Wilko Weichert, Matthias Kloor |
Jahr: | 2016 |
Umfang: | 7 S. |
Fussnoten: | Published online: 4 December 2015 ; Gesehen am 28.02.2020 |
Titel Quelle: | Enthalten in: Virchows Archiv |
Ort Quelle: | Berlin : Springer, 1847 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 468(2016), 3, Seite 313-319 |
ISSN Quelle: | 1432-2307 |
Abstract: | A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency, leading to accumulation of numerous mutations at repetitive DNA sequence stretches (microsatellites), known as high-level microsatellite instability (MSI-H). In colorectal cancer, MSI-H tumors show a clinical behavior different from microsatellite-stable (MSS) tumors. Data about the prevalence of MSI among non-small cell lung cancer (NSCLC) are conflicting, and clinical relevance of MSI is largely unknown. We analyzed a series of 480 pulmonary adenocarcinomas (ADC) for MSI using a sensitive mononucleotide marker panel (BAT25, BAT26, and CAT25). Positive cases were further analyzed by immunohistochemical staining for DNA mismatch repair proteins. Results were correlated with clinicopathological variables. MSI-H was detected in 4/480 (0.8 %) cases. In none of these, a background of Lynch syndrome was found. Three of the patients developed a metachronous carcinoma (esophagus, pancreas, and kidney). All MSI-H cases were stage I and occurred in smokers/ex-smokers. Mutations were found in EGFR (n = 2), KRAS (n = 1), or BRAF (n = 1). MSI-H neoplasms had a higher proliferative activity (38.7 %) than MSS neoplasms (28.3 %). Mean overall survival for MSS and MSI-H cases was 64.8 (CI 60.4-69.1) and 47.1 (CI 21-73.2) months, respectively. When specific mononucleotide marker panels are applied, the MSI-H phenotype is rare and predominantly found in early stage ADC of smokers. However, the frequency of MSI-H is in the range of other relevant molecular alterations. In the era of precision therapy, associations with distinct clinicopathological variables merit further investigation. |
DOI: | doi:10.1007/s00428-015-1892-7 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00428-015-1892-7 |
| Volltext: https://link.springer.com/article/10.1007%2Fs00428-015-1892-7 |
| DOI: https://doi.org/10.1007/s00428-015-1892-7 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 169126704X |
Verknüpfungen: | → Zeitschrift |
Microsatellite instability in pulmonary adenocarcinomas / Warth, Arne [VerfasserIn]; 2016 (Online-Ressource)