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Status: Bibliographieeintrag

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Verfasst von:Akbaba, Sati [VerfasserIn]   i
 Ahmed, Dina [VerfasserIn]   i
 Mock, Andreas [VerfasserIn]   i
 Held, Thomas [VerfasserIn]   i
 Bahadir, Suzan [VerfasserIn]   i
 Uzun-Lang, Kristin [VerfasserIn]   i
 Syed, Mustafa [VerfasserIn]   i
 Hörner-Rieber, Juliane [VerfasserIn]   i
 Forster, Tobias [VerfasserIn]   i
 Federspil, Philippe A. [VerfasserIn]   i
 Herfarth, Klaus [VerfasserIn]   i
 Plinkert, Peter K. [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Adeberg, Sebastian [VerfasserIn]   i
Titel:Treatment outcome of 227 patients with sinonasal adenoid cystic carcinoma (ACC) after intensity modulated radiotherapy and active raster-scanning carbon ion boost
Titelzusatz:a 10-year single-center experience
Verf.angabe:Sati Akbaba, Dina Ahmed, Andreas Mock, Thomas Held, Suzan Bahadir, Kristin Lang, Mustafa Syed, Juliane Hoerner-Rieber, Tobias Forster, Philippe Federspil, Klaus Herfarth, Peter Plinkert, Juergen Debus and Sebastian Adeberg
E-Jahr:2019
Jahr:1 November 2019
Umfang:14 S.
Fussnoten:Gesehen am 02.03.2020
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2019
Band/Heft Quelle:11(2019,11) Artikel-Nummer 1705, 14 Seiten
ISSN Quelle:2072-6694
Abstract:We aimed to evaluate the treatment outcome of primary and postoperative bimodal radiotherapy (RT) including intensity modulated photon radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) for sinonasal adenoid cystic carcinoma (ACC) patients. Medical records of 227 consecutive patients who received either a primary (n = 90, 40%) or postoperative (n = 137, 60%; R2, n = 86, 63%) IMRT with doses between 48 and 56 Gy in 1.8 or 2 Gy fractions and active raster-scanning carbon ion boost with 18 to 24 Gy (RBE, relative biological effectiveness) in 3 Gy (RBE) fractions between 2009 and 2019 up to a median total dose of 80 Gy (EQD2, equivalent dose in 2 Gy single dose fractions, range 71-80 Gy) were reviewed. Results: Median follow-up was 50 months. In univariate and multivariate analysis, no significant difference in local control (LC) could be shown between the two treatment groups (p = 0.33). Corresponding 3-year LC rates were 79% for primary bimodal RT and 82% for postoperative bimodal RT, respectively. T4 stage (p = 0.002) and solid histology (p = 0.005) were identified as independent prognostic factors for decreased LC. Significant worse long-term treatment tolerance was observed for postoperatively irradiated patients with 17% vs. 6% late grade 3 toxicity (p < 0.001). Primary radiotherapy including IMRT and carbon ion boost for dose-escalation results in adequate LC with less long-term grade 3 toxicity compared to postoperative bimodal radiotherapy in sinonasal ACC patients. The high rate of macroscopic tumor disease in the postoperative group makes the interpretation of the beneficial results in LC for primary RT difficult.
DOI:doi:10.3390/cancers11111705
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/cancers11111705
 kostenfrei: Volltext: https://www.mdpi.com/2072-6694/11/11/1705
 DOI: https://doi.org/10.3390/cancers11111705
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:adenoid cystic carcinoma
 carbon ion radiotherapy
 local control
 recurrence patterns
 sinonasal carcinoma
 toxicity
K10plus-PPN:1691325384
Verknüpfungen:→ Zeitschrift

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