Control of local immunity by airway epithelial cells

• Verfasst von: Weitnauer, Michael [VerfasserIn]
• Verfasst von: Mijošek, Vedrana [VerfasserIn]
• Verfasst von: Dalpke, Alexander [VerfasserIn]
• Titel: Control of local immunity by airway epithelial cells
• Verf.angabe: M. Weitnauer, V. Mijošek and A.H. Dalpke
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 12 S.
• Fussnoten: published online 2 December 2015 ; Gesehen am 03.03.2020
• Titel Quelle: Enthalten in: Mucosal immunology
• Ort Quelle: New York, NY : Nature Publishing Group, 2008
• Jahr Quelle: 2016
• Band/Heft Quelle: 9(2016), 2, Seite 287-298
• ISSN Quelle: 1935-3456
• DOI: doi:10.1038/mi.2015.126
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1691381586

Abstract

The lung is ventilated by thousand liters of air per day. Inevitably, the respiratory system comes into contact with airborne microbial compounds, most of them harmless contaminants. Airway epithelial cells are known to have innate sensor functions, thus being able to detect microbial danger. To avoid chronic inflammation, the pulmonary system has developed specific means to control local immune responses. Even though airway epithelial cells can act as proinflammatory promoters, we propose that under homeostatic conditions airway epithelial cells are important modulators of immune responses in the lung. In this review, we discuss epithelial cell regulatory functions that control reactivity of professional immune cells within the microenvironment of the airways and how these mechanisms are altered in pulmonary diseases. Regulation by epithelial cells can be divided into two mechanisms: (1) mediators regulate epithelial cells’ innate sensitivity in cis and (2) factors are produced that limit reactivity of immune cells in trans.