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Verfasst von:Balázs, Anita [VerfasserIn]   i
 Dürr, Julia [VerfasserIn]   i
 Zhou-Suckow, Zhe [VerfasserIn]   i
 Schatterny, Jolanthe [VerfasserIn]   i
 Mall, Marcus A. [VerfasserIn]   i
Titel:Ductal mucus obstruction and reduced fluid secretion are early defects in chronic pancreatitis
Verf.angabe:Anita Balázs, Zsolt Balla, Balázs Kui, József Maléth, Zoltán Rakonczay Jr., Julia Duerr, Zhe Zhou-Suckow, Jolanthe Schatterny, Matthias Sendler, Julia Mayerle, Jens-P. Kühn, László Tiszlavicz, Marcus A. Mall and Peter Hegyi
E-Jahr:2018
Jahr:29 May 2018
Umfang:11 S.
Fussnoten:Gesehen am 03.03.2020
Titel Quelle:Enthalten in: Frontiers in physiology
Ort Quelle:Lausanne : Frontiers Research Foundation, 2007
Jahr Quelle:2018
Band/Heft Quelle:9(2018) Artikel-Nummer 632, 11 Seiten
ISSN Quelle:1664-042X
Abstract:Objective: Defective mucus production in the pancreas may be an important factor in the initiation and progression of chronic pancreatitis (CP), therefore we aimed to (i) investigate the qualitative and quantitative changes of mucus both in human CP and in an experimental pancreatitis model and (ii) to correlate the mucus phenotype with epithelial ion transport function. Design: Utilizing human tissue samples and a murine model of cerulein induced CP we measured pancreatic ductal mucus content by morphometric analysis and the relative expression of different mucins in health and disease. Pancreatic fluid secretion in CP model was measured in vivo by magnetic resonance cholangiopancreatography (MRCP) and in vitro on cultured pancreatic ducts. Time-changes of ductal secretory function was correlated to those of the mucin production. Results: We demonstrate increased mucus content in the small pancreatic ducts in CP. Secretory mucins MUC6 and MUC5B were upregulated in human, Muc6 in mouse CP. In vivo and in vitro fluid secretion was decreased in cerulein-induced CP. Analysis of time-course changes showed that impaired ductal ion transport is paralleled by increased Muc6 expression. Conclusion: Mucus accumulation in the small ducts is a combined effect of mucus hypersecretion and epithelial fluid secretion defect, which may lead to ductal obstruction. These results suggest that imbalance of mucus homeostasis may have an important role in the early-phase development of CP, which may have novel diagnostic and therapeutic implications.
DOI:doi:10.3389/fphys.2018.00632
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3389/fphys.2018.00632
 Verlag: https://www.frontiersin.org/articles/10.3389/fphys.2018.00632/full
 DOI: https://doi.org/10.3389/fphys.2018.00632
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chronic pancreatitis
 ductal epithelium
 epithelial fluid secretion
 experimental pancreatitis
 Mucus
K10plus-PPN:1691414301
Verknüpfungen:→ Zeitschrift

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